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Methylene Blue trihydrate, Thermo Scientific Chemicals
Sensitive stain for RNA and ribonuclease
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Catalog number J60823.14
also known as J60823-14
Price (USD)/ Each
33.65
Online exclusive
37.60 Save 3.95 (11%)
-
Quantity:
25 g
Price (USD)/ Each
33.65
Online exclusive
37.60 Save 3.95 (11%)
Methylene Blue trihydrate, Thermo Scientific Chemicals
Catalog numberJ60823.14
Price (USD)/ Each
33.65
Online exclusive
37.60 Save 3.95 (11%)
-
Chemical Identifiers
CAS7220-79-3
IUPAC Name3,7-bis(dimethylamino)-5λ⁴-phenothiazin-5-ylium trihydrate chloride
Molecular FormulaC16H24ClN3O3S
InChI KeyXQAXGZLFSSPBMK-UHFFFAOYSA-M
SMILESO.O.O.[Cl-].CN(C)C1=CC2=[S+]C3=CC(=CC=C3N=C2C=C1)N(C)C
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Specifications
Specification Sheet
Specification SheetLoss on Drying8.0 to 18.0%
Assay (unspecified)0.02% Zinc max.
Assay (unspecified)98-103%
Assay (unspecified)0.02% Copper max.
Residue on ignition1.2% max.
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Methylene Blue trihydrate finds many uses in biology and chemistry. It acts as a GCS inhibitor, biological stain and redox indicator. It inhibits tau filament formation. Further, it is reported to bind to the M2 subtype of muscarinic receptors in rat cardiac myocytes and thus exhibit antimuscarinic effects on IK, ACh and ICa. It also inhibits endothelium-dependent relaxation of isolated blood vessels.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Methylene Blue trihydrate finds many uses in biology and chemistry. It acts as a GCS inhibitor, biological stain and redox indicator. It inhibits tau filament formation. Further, it is reported to bind to the M2 subtype of muscarinic receptors in rat cardiac myocytes and thus exhibit antimuscarinic effects on IK, ACh and ICa. It also inhibits endothelium-dependent relaxation of isolated blood vessels.
Solubility
Soluble in water, alcohol and chloroform. Insoluble in ether.
Notes
Incompatible with strong oxidizing agents.
Methylene Blue trihydrate finds many uses in biology and chemistry. It acts as a GCS inhibitor, biological stain and redox indicator. It inhibits tau filament formation. Further, it is reported to bind to the M2 subtype of muscarinic receptors in rat cardiac myocytes and thus exhibit antimuscarinic effects on IK, ACh and ICa. It also inhibits endothelium-dependent relaxation of isolated blood vessels.
Solubility
Soluble in water, alcohol and chloroform. Insoluble in ether.
Notes
Incompatible with strong oxidizing agents.
RUO – Research Use Only
General References:
- Xu, P.; Wang, J.; Xu, Y.; Chu, H.; Shen, H.; Zhang, D.; Zhao, M.; Liu, J.; Li, G. Binding Modes and Interaction Mechanism Between Different Base Pairs and Methylene Blue Trihydrate: A Quantum Mechanics Study. Adv. Struct. Bioinform. 2015, 827, 187-203.
- Chan, C. H.; Chia, C. H.; Zakaria, S.; Sajab, M. S.; Chin, S. X. Cellulose nanofibrils: a rapid adsorbent for the removal of methylene blue. RSC Adv. 2015, 5 (24), 18204-18212.