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Rifampin, Molecular Biology Reagent
Rifampin (rifampicin), CAS # 13292-46-1, is a synthetic rifamycin antibiotic that works by inhibiting RNA and DNA synthesis and exhibits activity against the tuberculosis microbe.
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Catalog number J60836.06
also known as J60836-06
Price (USD)/ Each
136.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
160.00 Save 23.35 (15%)
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Quantity:
5 g
Price (USD)/ Each
136.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
160.00 Save 23.35 (15%)
Rifampin, Molecular Biology Reagent
Catalog numberJ60836.06
Price (USD)/ Each
136.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
160.00 Save 23.35 (15%)
-
Chemical Identifiers
CAS13292-46-1
IUPAC Name2,15,17,29-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-{[(4-methylpiperazin-1-yl)amino]methylidene}-6,23,27-trioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1⁴,⁷.0⁵,²⁸]triaconta-1,3,5(28),9,19,21,25(29)-heptaen-13-yl acetate
Molecular FormulaC43H58N4O12
InChI KeyFZYOVNIOYYPUPY-UHFFFAOYNA-N
SMILESCOC1C=COC2(C)OC3=C(C)C(O)=C4C(O)=C(NC(=O)C(C)=CC=CC(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C)C(=CNN1CCN(C)CC1)C(=O)C4=C3C2=O
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Specifications
Specification Sheet
Specification SheetInfrared spectrumConforms
Appearance (Color)Red-brown
FormCrystals or powder or crystalline powder
Assay from Suppliers CofA≥95 to ≤103% (dry wt. basis, titration)
Assay from Suppliers CofAImpurity Rifampicin quinone: ≤ 1.5%
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Antibiotic effective against mycobacteria. Can also inhibit DNA polymeraseRifampin is an antibiotic used in the treatment of tuberculosis and its related microbacterial infections. It is involved in the inhibition of DNA polymerase and RNA polymerase. As an antipruritic agent, it is used in the autoimmune cholestatic liver disease and primary biliary cirrhosis (PBC).
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Rifampin is a rifamycin class antibiotic synthesized to resemble the compound isolated from Amycolatopsis rifamycinica
Applications
• Rifampin can be used as a bacteriostatic that prevents RNA and DNA synthesis, particularly in mycobacteria
• It may also act as an antineoplastic, a neuroprotective, and inhibitor of angiogenesis
WARNING: Reproductive Harm - www.P65Warnings.ca.gov
RUO – Research Use Only
General References:
- Tarakji, K.G.; Mittal, S.; Kennergren, C.; Corey, R.; Poole, J.E.; Schloss, E.; Gallastegui, J.; Pickett, R.A.; Evonich, R.; Philippon, F.; McComb, J.M., Roark, S.F.; Sorrentino, D.; Sholevar, D.; Cronin, E.; Berman, B., Riggio, D.; Biffi, M.; Khan, H.; Silver, M.T.; Collier, J.; Eldadah, Z.; Wright, D.J.; Lande, J.D.; Lexcen, D.R.; Cheng, A.; Wilkoff, B.L. WRAP-IT Investigators. Antibacterial Envelope to Prevent Cardiac Implantable Device Infection. N Engl J Med. 2019, 380(20), 1895-1905.
- Swindells, S.; Ramchandani, R.; Gupta, A.; Benson, C.A.; Leon-Cruz, J.; Mwelase, N.; Jean Juste, M.A.; Lama, J.R.; Valencia, J.; Omoz-Oarhe, A.; Supparatpinyo, K.; Masheto, G.; Mohapi L, da Silva Escada, R.O.; Mawlana, S.; Banda, P.; Severe, P.; Hakim, J.; Kanyama, C.; Langat, D.; Moran, L.; Andersen, J.; Fletcher, C.V.; Nuermberger, E.; Chaisson, R.E., BRIEF TB/A5279 Study Team. One Month of Rifapentine plus Isoniazid to Prevent HIV-Related Tuberculosis. N Engl J Med. 2019, 380(11), 1001-1011.