Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Dextran is a glucose polymer biosynthesized by the non-pathogenic Leuconostoc mesenteroides
Application
• Dextran is a complex branched glucan that can be used to enhance electronegativity and reduce erythrocyte aggregation and platelet adhesiveness (anticoagulant activity)
• This compound promotes the activation of plasminogen by inhibiting α-2 antiplasmin
• Dextran can be used to reduce thrombosis in animal models
• It is used in osmotic stress techniques where osmotic pressure is applied to biological molecules • Dextran can be used as an immobilization agent in biosensors
Literature References
Zhang, Z.; Amorosa, L. F.; Coyle, S. M.; Macor, M. A.; Lubitz, S. E.; Carson, J. L.; Birnbaum, M. J.; Lee, L. Y.; Haimovich, B. Proteolytic Cleavage of AMPK alpha and Intracellular MMP9 Expression Are Both Required for TLR4-Mediated mTORC1 Activation and HIF-1alpha Expression in Leukocytes. J. Immunol. 2015, 195 (5), 2452-2460.
Kim, N. H.; Pham, N. B.; Quinn, R. J.; Shim, J. S.; Cho, H.; Cho, S. M.; Park, S. W.; Kim, J. H.; Seok, S. H.; Oh, J. W.; Kwon, H. J. The Small Molecule R-(-)-beta-O-Methylsynephrine Binds to Nucleoporin 153 kDa and Inhibits Angiogenesis. Int J Biol Sci. 2015, 11 (9), 1088-1099.