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Colchicine, 98%, Thermo Scientific Chemicals
Catalog number: J61072.06
5 g, Each
Thermo Scientific Chemicals
Colchicine, 98%, Thermo Scientific Chemicals
Catalog number: J61072.06
5 g, Each
Quantity
Catalog number: J61072.06
also known as J61072-06
Price (USD)
Special offer:
307.65 325.65 Online priceSave 18.00 (5%)
Ends: 15-Oct-2024
Each
Quantity
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Chemical Identifiers
CAS
64-86-8
IUPAC Name
N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0²,⁷]hexadeca-1(16),2,4,6,11,14-hexaen-10-yl]acetamide
Molecular Formula
C22H25NO6
InChI Key
IAKHMKGGTNLKSZ-INIZCTEOSA-N
SMILES
COC1=C(OC)C(OC)=C2C(CC[C@H](NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1
Specifications
Specification SheetForm
Powder
Appearance (Color)
White to pale yellow
Comment
Solubility: DMSO 25mg/ml, Ethanol 25mg/ml
Assay from Supplier's CofA
≥97.5%
Proton NMR
Conforms to structure
Description
Colchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Colchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Solubility
Soluble in ethanol (10 mg/ml), water (45 g/L), chloroform, DMSO and methanol.
Notes
Light sensitive. Incompatible with oxidizing agents.
Colchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Solubility
Soluble in ethanol (10 mg/ml), water (45 g/L), chloroform, DMSO and methanol.
Notes
Light sensitive. Incompatible with oxidizing agents.
WARNING: Reproductive Harm - www.P65Warnings.ca.gov
RUO – Research Use Only
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