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Colchicine, 98%, Thermo Scientific Chemicals
Microtubule disrupting agent, and induces apoptosis in human lymphoma cells
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Catalog number J61072.ME
also known as J61072-ME
Price (USD)/ Each
57.65
Online exclusive
63.60 Save 5.95 (9%)
-
Quantity:
500 mg
Price (USD)/ Each
57.65
Online exclusive
63.60 Save 5.95 (9%)
Colchicine, 98%, Thermo Scientific Chemicals
Catalog numberJ61072.ME
Price (USD)/ Each
57.65
Online exclusive
63.60 Save 5.95 (9%)
-
Chemical Identifiers
CAS64-86-8
IUPAC NameN-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0²,⁷]hexadeca-1(16),2,4,6,11,14-hexaen-10-yl]acetamide
Molecular FormulaC22H25NO6
InChI KeyIAKHMKGGTNLKSZ-INIZCTEOSA-N
SMILESCOC1=C(OC)C(OC)=C2C(CC[C@H](NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1
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Specifications
Specification Sheet
Specification SheetFormPowder
Appearance (Color)White to pale yellow
CommentSolubility: DMSO 25mg/ml, Ethanol 25mg/ml
Assay from Supplier's CofA≥97.5%
Proton NMRConforms to structure
Colchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Colchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Solubility
Soluble in ethanol (10 mg/ml), water (45 g/L), chloroform, DMSO and methanol.
Notes
Light sensitive. Incompatible with oxidizing agents.
Colchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Solubility
Soluble in ethanol (10 mg/ml), water (45 g/L), chloroform, DMSO and methanol.
Notes
Light sensitive. Incompatible with oxidizing agents.
WARNING: Reproductive Harm - www.P65Warnings.ca.gov
RUO – Research Use Only
General References:
- A.D.Caperta; M.Delgado; F.Ressurreicao; A.Meister; R.N.Jones; W.Viegas; A.Houben. Colchicine-induced polyploidization depends on tubulin polymerization in c-metaphase cells. Protoplasma. 2006, 227,(2-4), 147-153.
- A.B.Mendes-Bonato; M.Ferrari Felismino; A.M.Souza Kaneshima; C.Pessim; V.Calisto; M.Suely Pagliarini; C.Borges do Valle. Abnormal meiosis in tetraploid genotypes of Brachiaria brizantha (Poaceae) induced by colchicine: its implications for breeding. Journal of Applied Genetics. 2009, 50,(2), 83-87.