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Paromomycin sulfate, Thermo Scientific Chemicals
Inhibits initiation and elongation during protein synthesis
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Catalog number J61274.03
also known as J61274-03
Price (USD)/ Each
44.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
52.40 Save 7.75 (15%)
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Quantity:
1 g
Price (USD)/ Each
44.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
52.40 Save 7.75 (15%)
Paromomycin sulfate, Thermo Scientific Chemicals
Catalog numberJ61274.03
Price (USD)/ Each
44.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
52.40 Save 7.75 (15%)
-
Chemical Identifiers
CAS1263-89-4
IUPAC Name(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(2R,3S,4R)-5-{[(1R,3S,5R,6S)-3,5-diamino-2-{[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-hydroxycyclohexyl]oxy}-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}oxane-3,4-diol; sulfuric acid
Molecular FormulaC23H47N5O18S
InChI KeyLJRDOKAZOAKLDU-UMIPPVEZSA-N
SMILESOS(O)(=O)=O.NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)OC(O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)C3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O
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Specifications
Specification Sheet
Specification SheetAppearance (Color)White to pale cream to pale yellow
FormPowder
Assay from Supplier's CofA≥675 U/mg
Loss on Drying≤5.0%
Paromomycin sulfate salt has been used as a reference compound in antileishmanial activity, RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex. It has also been used in cell culture applications at 100mg/L. Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Paromomycin sulfate salt has been used as a reference compound in antileishmanial activity, RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex. It has also been used in cell culture applications at 100mg/L. Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.
Solubility
Soluble in water
Notes
Research Use only: Not intended for animal or human diagnostic or therapeutic use.
Paromomycin sulfate salt has been used as a reference compound in antileishmanial activity, RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex. It has also been used in cell culture applications at 100mg/L. Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.
Solubility
Soluble in water
Notes
Research Use only: Not intended for animal or human diagnostic or therapeutic use.
WARNING: Reproductive Harm - www.P65Warnings.ca.gov
RUO – Research Use Only
General References:
- Begley U et al. A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-a. EMBO Mol Med . 2013, 5,(3), 366-83.
- Goossens J et al. Porcine intestinal epithelial barrier disruption by the Fusarium mycotoxins deoxynivalenol and T-2 toxin promotes transepithelial passage of doxycycline and paromomycin. BMC Vet Res. 2012, 8,(245), 6148-8.