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Streptomycin sulfate, Cell Culture Reagent
Streptomycin sulfate, CAS # 3810-74-0, is the sulfate salt form of streptomycin, and an aminoglycoside with antibacterial activity. It also shows a protein synthesis inhibitory activity. | CAS: 3810-74-0 | C42H84N14O36S3 | 1457.376 g/mol
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Catalog number J61299.22
also known as J61299-22
Price (USD)
95.30
Each
Quantity:
100 g
Price (USD)
95.30
Each
Chemical Identifiers
CAS3810-74-0
IUPAC Namebis(N''-[(1R,2R,3S,4R,5R,6S)-3-[(diaminomethylidene)amino]-4-{[(2R,3R,4R,5S)-3-{[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy}-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy}-2,5,6-trihydroxycyclohexyl]guanidine); tris(sulfuric acid)
Molecular FormulaC42H84N14O36S3
InChI KeyQTENRWWVYAAPBI-YCRXJPFRSA-N
SMILESOS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](N=C(N)N)[C@@H](O)[C@@H]2N=C(N)N)O[C@@H](C)[C@]1(O)C=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](N=C(N)N)[C@@H](O)[C@@H]2N=C(N)N)O[C@@H](C)[C@]1(O)C=O
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Specifications
Specification Sheet
Specification SheetCommentColorimetric: ≥ 90.0%
Impurity contentMethanol (GC): ≤ 0.3%
Loss on Drying≤ 7.0%
Assay (unspecified)(Sulfate): 18.0 - 21.5%
Impurity contentBacterial Endotoxins: ≤ 0.25 IU/mg
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Inhibits initiation and causes misreading of rRNA in protein synthesis Streptomycin sulfate is used to study the mechanisms of streptomycin resistance. It is used to inhibit bacterial contamination in cell culture applications in association with penicillin. It is an antibiotic drug initially used for tuberculosis treatment. It inhibits protein synthesis by binding to 30S ribosomal subunit, which induces the misreading of the genetic code. It is involved in the initiation of translation of DNA, thereby results in death for a susceptible bacterium. Further, it controls bacterial and fungal diseases of certain fruit, vegetables, seed, ornamental crops and algae in ornamental ponds and aquaria
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Streptomycin sulfate is an aminoglycoside sulfate salt derived from Streptomyces griseus that shows antibacterial activity.
- It inhibits the initiation and causes misreading of rRNA in protein synthesis. This compound binds to the S12 protein of the bacterial 30S ribosomal subunit, thereby inhibiting peptide elongation and protein synthesis.
Application
- Streptomycin sulfate can be used to study the mechanisms of streptomycin resistance
- This compound can be used in laboratory applications combined with penicillin to inhibit bacterial contamination in in vitro cell culture
- Streptomycin sulfate shows antibiotic activity against Mycobacterium tuberculosis
- This compound can be used as a protein synthesis inhibitor
- It acts against gram-negative and gram-positive bacteria
- Streptomycin sulfate also shows a fungicide activity
- It can be used to remove nucleic acids from a biological extract
WARNING: Reproductive Harm - www.P65Warnings.ca.gov
RUO – Research Use Only
General References:
- Kou, Q. Y.; Li, J.; Zhao, B.; Wu, Z. L. Recovery of streptomycin sulfate from the wastewater using foam fractionation coupled with adsorption separation for reusing sodium dodecyl sulfate. J. Chem. Technol. Biotechnol. 2015, 90 (5), 874-879.
- Evans, J. F.; Salvador, V.; George, S.; Trevino-Gutierrez, C.; Nunez, C. Mouse aorta-derived mesenchymal progenitor cells contribute to and enhance the immune response of macrophage cells under inflammatory conditions. Stem Cell Res. Ther. 2015, 6 (56), 1-15.