5-Iodo-2'-deoxycytidine is used in the construction of DNA oligomers to enable structural studies and photoactivated cross-linking. It is used in the synthesis of other modified nucleosides, such as 5-ethynylferrocenyl-2?-deoxycytidine used in semiconductor electrodes and 10-(2-deoxyβ-D-ribofuranosyl)pyrimido[4,5:4,5]pyrimido[1,6-a]indole-6,9(7H)-dione (dCPPI).
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
5-Iodo-2′-deoxycytidine is used in the construction of DNA oligomers to enable structural studies and photoactivated cross-linking. It is used in the synthesis of other modified nucleosides, such as 5-ethynylferrocenyl-2′-deoxycytidine used in semiconductor electrodes and 10-(2-deoxyβ-D-ribofuranosyl)pyrimido[4′,5′:4,5]pyrimido[1,6-a]indole-6,9(7H)-dione (dCPPI).
Solubility
Slightly soluble in water.
Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents and heat.
RUO – Research Use Only
Masahiro Mizuta; Kohji Seio; Kenichi Miyata; Mitsuo Sekine. Fluorescent pyrimidopyrimidoindole nucleosides: control of photophysical characterizations by substituent effects. Journal of Organic Chemistry. 2007, 72,(14), 5046-5055.
Andrew R.Pike; Lyndsey C.Ryder; Benjamin R.Horrocks; William Clegg; Bernard A.Connolly; Andrew Houlton. Ferrocenyl-modified DNA: synthesis, characterization and integration with semiconductor electrodes. Chemistry: A European Journal. 2004, 11,(1), 344-353.