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Amphotericin B, Streptomyces nodosus, Thermo Scientific Chemicals
Catalog number: J61491.MC
100 mg, Each
Thermo Scientific Chemicals
Amphotericin B, Streptomyces nodosus, Thermo Scientific Chemicals
Catalog number: J61491.MC
100 mg, Each
Quantity
Catalog number: J61491.MC
also known as J61491-MC
Price (USD)
Special offer:
57.65 68.00 Save 10.35 (15%)
Ends: 15-Oct-2024
Each
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Chemical Identifiers
CAS
1397-89-3
IUPAC Name
(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19Z,21Z,23Z,25Z,27Z,29Z,31Z,33R,35S,36R,37S)-33-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
Molecular Formula
C47H73NO17
InChI Key
APKFDSVGJQXUKY-ZNVUZQDLSA-N
SMILES
C[C@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@@](O)(C[C@H](O)[C@H]3C(O)=O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C/C=C\C=C/C=C\C=C/C=C\C=C/2)[C@@H](O)[C@@H](N)[C@@H]1O
Specifications
Specification SheetAssay (unspecified)
Amphotericin A: 15.0% max.
Assay (unspecified)
Potency: 750 ?g/mg min.
Loss on Drying
5.0% max.
Description
Amphotericin B, antifungal activity has been used against leishmaniasis caused by protozoan parasites of the Leishmania genus. Amphotericin B trihydrate was observed to cause suppression of bone marrow progenitor cells and to induce Actinomycin D(CR001) sensitivity in drug resistant HELA cells in vitro.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Amphotericin B is an antibiotic that has antifungal activity and is produced mainly by Streptomyces nodosus
Applications
• It has antifungal activity against fungus caused by protozoan parasites of Leishmania genus by binding to an essential component of the fungal cell membrane and altering cell membrane permeability
• It can suppress bone marrow progenitor cells and induce Actinomycin D(CR001) sensitivity in drug resistant HELA cells in vitro
RUO – Research Use Only
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