Histamine inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H2 receptor activation. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
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Applications
Histamine inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H2 receptor activation. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Solubility
Soluble in water, alcohol, and hot chloroform.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C Hygroscopic. Handle and store under inert gas. Air sensitive.
RUO – Research Use Only
PA Shore.; A Burkhalter.; VH Cohn. A method for the fluorometric assay of histamine in tissues. JPET. 1959, 127, (3), 182-186.
JM Arrang.; M Garbarg.; JC Schwartz. Auto-inhibition of brain histamine release mediated by a novel class (H3) of histaminereceptor. Nature. 1983, 302, (3), 832 - 837.