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Oligomycin, Thermo Scientific Chemicals
Oligomycin, CAS # 1404-19-9, is a macrolide antibiotic that inhibits oxidative phosphorylation through blocking mitochondrial ATP synthase.
Catalog number J61898.MA
also known as J61898-MA
Price (USD)/ Each
229.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
270.00 Save 40.35 (15%)
-
Quantity:
10 mg
Price (USD)/ Each
229.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
270.00 Save 40.35 (15%)
Oligomycin, Thermo Scientific Chemicals
Catalog numberJ61898.MA
Price (USD)/ Each
229.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
270.00 Save 40.35 (15%)
-
Specifications
Chemical Name or MaterialOligomycin
TypeOligomycin
Physical FormPowder
CAS1404-19-9
Recommended StorageStore at -20°C
View more
Inhibits respiration in mitochondria. Also inhibits ATP synthase
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Oligomycin is a macrolide produced by Streptomyces diastatochromogenes that is toxic to other organisms
• Oligomycin blocks oxidative phosphorylation through inhibition of ATP synthase. The compound binds to the proton channel of ATP synthase and blocks mitochondrial proton import, resulting in accumulation of cytoplasmic protons
• Oligomycin also inhibits Na+/K+ exchange through Na+ occlusion within the Na/K-ATPase
• Oligomycin is provided as a mixture of A, B, and C isomers
Application
• Oligomycin inhibits respiration in mitochondria. It also inhibits ATP synthase
• Oligomycin can induce apoptosis in cultured human hepatocarcinoma and other mammalian cells in laboratory settings
RUO – Research Use Only
General References:
- Frizzell, N and Stillway, L.W. Medical Biochemistry, Chapter 8, 93-110. Elsevier 2019.
- Ding Y, Hao J, Rakowski RF. Effects of oligomycin on transient currents carried by Na+ translocation of Bufo Na+/K(+)-ATPase expressed in Xenopus oocytes. J Membr Biol. 2011 Oct;243(1-3):35-46. doi: 10.1007/s00232-011-9390-6. Epub 2011 Aug 30. PMID: 21877177.