Fluconazole, 99%, Thermo Scientific Chemicals
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Fluconazole, 99%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Fluconazole, 99%, Thermo Scientific Chemicals

Fluconazole, CAS # 86386-73-4, is a synthetic triazole with antifungal activity against some species of Candida. It also shows inhibitory activity against cytochrome P-450 enzymes and it is a demethylase.
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Catalog number J62015.06
also known as J62015-06
Price (USD)/ Each
325.65
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362.00 
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Quantity:
5 g
Request bulk or custom format
Price (USD)/ Each
325.65
Online exclusive
362.00 
Save 36.35 (10%)
Add to cart
Fluconazole, 99%, Thermo Scientific Chemicals
Catalog numberJ62015.06
Price (USD)/ Each
325.65
Online exclusive
362.00 
Save 36.35 (10%)
-
Add to cart
Chemical Identifiers
CAS86386-73-4
IUPAC Name2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
Molecular FormulaC13H12F2N6O
InChI KeyRFHAOTPXVQNOHP-UHFFFAOYSA-N
SMILESOC(CN1C=NC=N1)(CN1C=NC=N1)C1=CC=C(F)C=C1F
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SpecificationsSpecification SheetSpecification Sheet
FormPowder
Appearance (Color)White to pale cream
Assay (special)≥99.0%
Fluconazole is used to treat a variety of fungal infections, especially Candida infections of the vagina (yeast infections), mouth, throat and bloodstream. It is also used by the people having weak immune system such as persons with neutropenia due to cancer chemotherapy, transplanted patients and premature infants.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description
• Fluconazole, 98% is a triazole compound showing antifungal activity mainly against Candida, Coccidioides, and Cryptococcus species
• It has been shown to inhibit fungal cytochrome P-450 sterol C-14 α-demethylation, resulting in the accumulation of fungal 14 α-methyl sterols, the loss of normal fungal sterols, and associated fungistatic activity
• It also inhibits cytochrome P450 family 2 subfamily c member 9 (CYP2C9)
• Mammalian cell demethylation is much less susceptible to fluconazole inhibition
Applications
• Fluconazole has fungistatic activity against many fungal strains including Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and Cryptococcus neoformans.
• Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene
• In biological experiments, this compound has been used to assess minimum inhibitory concentration in (MIC)-fungal assays
• It has also been used as a positive control in antifungal assay of plants
RUO – Research Use Only

General References:

  1. Clancy, C.J.; Yu, V.L.; Morris, A.J.; Snydman, D.R.; Nguyen, M.H. Fluconazole MIC and the fluconazole dose/MIC ratio correlate with therapeutic response among patients with candidemia. Antimicrob Agents Chemother. 2005, 49 (8), 3171-3177.
  2. Matsui, K.; Tsume, Y.; Amidon, G. E.; Amidon, G. L. In Vitro Dissolution of Fluconazole and Dipyridamole in Gastrointestinal Simulator (GIS), Predicting in Vivo Dissolution and Drug-Drug Interaction Caused by Acid-Reducing Agents. Mol. Pharmaceutics. 2015, 12 (7), 2418-2428.
  3. Bhardwaj, T.; Bhardwaj, V.; Sharma, K.; Gupta, A.; Cameotra, S. S.; Sharma, P. Thermo-acoustical analysis of sodium dodecyl sulfate: Fluconazole (antifungal drug) based micellar system in hydro-ethanol solutions for potential drug topical application. J. Chem. Thermodyn. 2014, 78, 1-6.