General Description

• Rapamycin is a natural macrolide compound showing antiproliferative activities in mammalian cells
• Rapamycin is a specific inhibitor of rapamycin kinase. It forms a complex with FKBP12 that consequently binds and inhibits rapamycin’s molecular target (rapamycin kinase)

Application

• Rapamycin inhibits tumor growth by preventing tumor cell proliferation and suppressing tumor angiogenesis
• This compound also blocks cytokine-mediated signal transduction pathways
• Rapamycin also promotes the suppression of the immune system
• It was initially defined as an antifungal metabolite produced by Streptomyces hygroscopicus
• In vitro studies demonstrated that this compound is an important mediator of PI3 kinase signaling