Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General description
• G418 sulfate (geneticin) is an aminoglycoside antibiotic isolated from Micromonospora rhodorangea
• G418 is a bacteriostatic that prevents polypeptide formation by inhibiting the elongation step of polypeptide synthesis
Applications
• G418 sulfate can be used for selection of genetically engineered cells in both eukaryotes and prokaryotes
• Laboratory grade for applications such as biochemistry
Literature references
Arshad, H.; Patel, Z.; Mehrabian, M.; Bourkas, M.; Al-Azzawi, Z.; Schmitt-Ulms, G., & Watts, J. C. 2021. The aminoglycoside G418 hinders de novo prion infection in cultured cells. The Journal of biological chemistry, 297(3), 101073.
Ferguson, M. W.; Gerak, C.; Chow, C.; Rastelli, E. J.; Elmore, K. E.; Stahl, F.; Hosseini-Farahabadi, S.; Baradaran-Heravi, A.; Coltart, D. M., & Roberge, M. 2019. The antimalarial drug mefloquine enhances TP53 premature termination codon readthrough by aminoglycoside G418. PloS one, 14(5), e0216423.