Paclitaxel, 99.5+%, Thermo Scientific Chemicals
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Paclitaxel, 99.5+%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Paclitaxel, 99.5+%, Thermo Scientific Chemicals

Paclitaxel (CAS # 33069-62-4) is a microtubule inhibitor produced from the extract of the Pacific yew tree.
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Catalog number J62734.03
Price (USD)/ Each
654.65
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727.00 
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Quantity:
1 g
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Price (USD)/ Each
654.65
Online exclusive
727.00 
Save 72.35 (10%)
Add to cart
Paclitaxel, 99.5+%, Thermo Scientific Chemicals
Catalog numberJ62734.03
Price (USD)/ Each
654.65
Online exclusive
727.00 
Save 72.35 (10%)
-
Add to cart
Chemical Identifiers
CAS33069-62-4
IUPAC Name(1S,2S,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0³,¹⁰.0⁴,⁷]heptadec-13-en-2-yl benzoate
Molecular FormulaC47H51NO14
InChI KeyRCINICONZNJXQF-VAZQATRQSA-N
SMILESCC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)C3=CC=CC=C3)C3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)C1=CC=CC=C1)C1=CC=CC=C1
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)White to cream
Assay from Suppliers CofA≥99.5% (HPLC)
FormCrystalline powder or granular
Promotes assembly and inhibits disassembly of microtubules (anti-cancer agent)Paclitaxel is widely used in chemotherapeutic compound. It is used to treat certain types of cancer such as ovarian cancer, breast cancer, lung cancer and pancreatic cancer among others. It interferes with the growth of cancer cells and slows down their growth and spread in the body. It is also used to treat AIDS-related Kaposi's sarcoma.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Paclitaxel is a tetracyclic diterpenoid isolated from the Pacific yew, Taxus brevifolia
  • Paclitaxel acts as an antineoplastic agent by binding tubulin and preventing cell division
  • Paclitaxel may also bind Bcl-2 and lead to disinhibition of apoptosis

Application

  • Paclitaxel is used in the study of lung, breast, and ovarian cancers; it may be useful in the research of other cancer types
  • It is suitable for cell culture, biochemistry, and molecular biology applications
WARNING: Reproductive Harm - www.P65Warnings.ca.gov
RUO – Research Use Only

General References:

  1. England, C. G.; Miller, M. C.; Kuttan, A.; Trent, J. O.; Frieboes, H. B. Release kinetics of paclitaxel and cisplatin from two and three layered gold nanoparticles. Eur. J. Pharm. Biopharm. 2015, 92, 120-129.
  2. Liu, Y.; Ran, R.; Chen, J.; Kuang, Q.; Tang, J.; Mei, L.; Zhang, Q.; Gao, H.; Zhang, Z.; He, Q. (2014). Paclitaxel loaded liposomes decorated with a multifunctional tandem peptide for glioma targeting. Biomaterials 2014, 35 (17), 4835-4847.