Nifedipine, 98%, Thermo Scientific Chemicals
Nifedipine, 98%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Nifedipine, 98%, Thermo Scientific Chemicals

L-type calcium channel blocker; induces apoptosis in human glioblastoma cells
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100 g
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25 g
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Catalog number J62811.22
also known as J62811-22
Price (USD)/ Each
593.00
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Quantity:
100 g
Request bulk or custom format
Price (USD)/ Each
593.00
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Nifedipine, 98%, Thermo Scientific Chemicals
Catalog numberJ62811.22
Price (USD)/ Each
593.00
-
Add to cart
Chemical Identifiers
CAS21829-25-4
IUPAC Name3,5-dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Molecular FormulaC17H18N2O6
InChI KeyHYIMSNHJOBLJNT-UHFFFAOYSA-N
SMILESCOC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC=C1[N+]([O-])=O)C(=O)OC
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SpecificationsSpecification SheetSpecification Sheet
Proton NMRConforms
FormPowder or crystals or crystalline powder
Appearance (Color)Yellow
Assay from Suppliers CofA≥97.5%
L-type calcium channel blocker; induces apoptosis in human glioblastoma cells.Nifedipine is a dihydropyridine calcium channel blocker used as L-type calcium channel blocker, antianginal and an antihypertensive . It induces apoptosis in human glioblastoma cells. It is used as a coronary vasodilator in the treatment of cardiac and circulatory disorders. Further, it is used in high-altitude medicine to treat high altitude pulmonary edema, hypertension and chronic stable angina. In addition, it is frequently used as a tocolytic agent.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
L-type calcium channel blocker; induces apoptosis in human glioblastoma cells.Nifedipine is a dihydropyridine calcium channel blocker used as L-type calcium channel blocker, antianginal and an antihypertensive . It induces apoptosis in human glioblastoma cells. It is used as a coronary vasodilator in the treatment of cardiac and circulatory disorders. Further, it is used in high-altitude medicine to treat high altitude pulmonary edema, hypertension and chronic stable angina. In addition, it is frequently used as a tocolytic agent.

Solubility
Soluble in acetone, methylene chloride, chloroform, ethyl acetate, dimethyl sulfoxide and methanol. Sparingly soluble in ethanol. Insoluble in water.

Notes
Light sensitive. Store in a cool place. Incompatible with strong acids, strong oxidizing agents, caustics, aliphatic amines, amides, diethylamine, potassium hydride and potassium hydroxide.
WARNING: Reproductive Harm - www.P65Warnings.ca.gov
RUO – Research Use Only

General References:

  1. Weerapol, Y.; Limmatvapirat, S.; Jansakul, C.; Takeuchi, H.; Sriamornsak, P. Enhanced dissolution and oral bioavailability of nifedipine by spontaneous emulsifying powders: Effect of solid carriers and dietary state. Eur. J. Pharm. Biopharm. 2015, 91, 25-34.
  2. Miao, X. N.; Siu, K. L.; Cai, H. Nifedipine attenuation of abdominal aortic aneurysm in hypertensive and non-hypertensive mice: Mechanisms and implications. J. Mol. Cell. Cardiol. 2015, 87, 152-159.