Cimetidine, 98+%, Thermo Scientific Chemicals
Cimetidine, 98+%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Cimetidine, 98+%, Thermo Scientific Chemicals

H2 histamine receptor antagonist
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Catalog number J62825.06
also known as J62825-06
Price (USD)/ Each
83.20
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Quantity:
5 g
Request bulk or custom format
Price (USD)/ Each
83.20
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Cimetidine, 98+%, Thermo Scientific Chemicals
Catalog numberJ62825.06
Price (USD)/ Each
83.20
-
Add to cart
Chemical Identifiers
CAS51481-61-9
IUPAC NameN-cyano-N''-methyl-N'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine
Molecular FormulaC10H16N6S
InChI KeyAQIXAKUUQRKLND-UHFFFAOYSA-N
SMILESCN=C(NCCSCC1=C(C)NC=N1)NC#N
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)White to off-white
Mass SpecConforms
Purity≥98.0%
FormPowder
Widely used H2 histamine antagonist which has more recently been described as an inverse agonist. Also a potent I1 imidazoline binding site ligand. It displays antitumor and immunomodulatory activity. Cimetidine competitively inhibits histamine binding to histamine H2 receptors, and suppresses the growth of several tumors, including gastrointestinal cancer. This compound is an anti-angiogenic agent and is an activator of Nischarin. Competitive histamine H2-receptor antagonist which inhibits gastric acid secretion and reduces pepsin output

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble to 50 mM in water and to 100 mM in DMSO, solubility in HCl (almost transparency).

Notes
Store away from heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
RUO – Research Use Only

General References:

  1. Yasui-Furukori N, et al. Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics.Clinical pharmacology and therapeutics.,2005,77(1), 17-23.
  2. Yoshizawa F, et al. Time course of leucine-induced 4E-BP1 and S6K1 phosphorylation in the liver and skeletal muscle of rats.Journal of clinical pharmacology.,1981,21(2), 87-91.