Penicillin G sodium salt is used as a β-lactam antibiotic. Penicillin G can be used as a selective agent in several types of isolation media. It has been used to study the diagnostic and therapeutic implications of gentamicin-resistant Enterococcus faecalis sequence type 6 with reduced penicillin susceptibility and in cell culture both alone and combined with streptomycin and other antibiotics.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Penicillin G sodium salt is the sodium salt of benzylpenicillin, a broad-spectrum β-lactam antibiotic with gram-positive and gram-negative bactericidal activity
• Penicillin G binds and inactivates penicillin-binding-proteins associated with the bacterial cell wall, thus inhibiting cell wall synthesis and resulting in cell lysis
Applications
• Penicillin G can be used as a selection agent in the isolation of microorganisms or in cell culture applications
• It can also be used to prevent infection in research animals
RUO – Research Use Only
Literature references
Livermore, D.M. beta-Lactamases- the Threat Renews. Curr. Protein Pept. Sci. 2009, 10, (5), 397-400.
Demain, A.L. Production of beta-lactam antibiotics and its regulation. Proc. Natl. Sci. Counc. Repub. China B. 1991, 15, (4), 251-65.