Polymixin B sulfate
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Polymixin B sulfate
Thermo Scientific Chemicals

Polymixin B sulfate

Polymixin B sulfate, CAS # 1405-20-5, is a short polypeptide with antibacterial activity against gram-negative bacteria.
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Catalog number J63074.06
Price (USD)/ Each
437.65
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Ends: 31-Dec-2024
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Quantity:
5g
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Price (USD)/ Each
437.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
515.00 
Save 77.35 (15%)
Add to cart
Polymixin B sulfate
Catalog numberJ63074.06
Price (USD)/ Each
437.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
515.00 
Save 77.35 (15%)
-
Add to cart
Chemical Identifiers
CAS1405-20-5
IUPAC Name4-amino-N-{1-[(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(2-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)carbamoyl]-3-hydroxypropyl}-2-formamidobutanamide; sulfuric acid
Molecular FormulaC48H84N16O17S
InChI KeyHNDFYNOVSOOGDU-UHFFFAOYNA-N
SMILESOS(O)(=O)=O.CC(C)CC1NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCN)NC(=O)C(CCNC(=O)C(CCO)NC(=O)C(CCN)NC(=O)C(CCN)NC1=O)NC(=O)C(CCN)NC(=O)C(CCO)NC(=O)C(CCN)NC=O
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SpecificationsSpecification SheetSpecification Sheet
Assay from Suppliers CofA≥80%
FormPowder or crystalline powder
Appearance (Color)White to pale yellow
Antibiotic for gram-negative bacteria Polymyxin B Sulfate is an antibiotic mixture active against gram (-) organisms. It is also reported to inhibit Ca2+ dependent PKC (protein kinase C).

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Polymixin B sulfate is a mixture of B1 and B2 polypeptides obtained from different strains of Bacillus polymyxa, with antibacterial activity against gram-negative bacteria. It does not exhibit activity against fungi and gram-positive organisms
  • This compound inhibits Ca2+ dependent PKC (protein kinase C)
  • It can bind lipopolysaccharide (LPS) of the outer membrane of gram-negative bacteria and disrupts the cytoplasmic membrane by inducing large pores to allow nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane

Application

  • Polymixin B sulfate targets BAC-1.2F5 murine macrophages as an LPS (lipopolysaccharide) inhibitor
  • In in vitro research, this compound is used to prevent bacterial contamination of cell cultures
  • In microbiology research, it is used as a positive and negative control during microbicidal concentration (MCC) assay
RUO – Research Use Only
Contents & Storage
Keep cold