Dextran, MW ca 150,000, Thermo Scientific Chemicals
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Dextran, MW ca 150,000, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Dextran, MW ca 150,000, Thermo Scientific Chemicals

Dextran, CAS # 9004-54-0, is a glucose polymer. It is mainly used to increase electronegativity and reduce erythrocyte aggregation and platelet adhesiveness (anticoagulant activity).
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Catalog number J63789.22
also known as J63789-22
Price (USD)/ Each
155.00
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Quantity:
100 g
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Price (USD)/ Each
155.00
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Dextran, MW ca 150,000, Thermo Scientific Chemicals
Catalog numberJ63789.22
Price (USD)/ Each
155.00
-
Add to cart
Chemical Identifiers
CAS9004-54-0
IUPAC NameDextran
Molecular Formula(C6H9O5)n(C6H10O5)m
SMILESO[C@@H]1[C@@H](O)[C@@H](-*)O[C@H](CO[C@H]2O[C@H](CO-*)[C@@H](O)[C@H](O-*)[C@H]2O)[C@H]1O
MDL NumberMFCD00130935
SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)White to pale cream
Ash≤2.0%
pH4.5-7.0 (6% solution in water)
FormPowder
Optical Rotation+195 to +203° (20°C, 2% solution in water)
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Dextran is used in a bead form to aid in bioreactor applications, some size-exclusion chromatography matrices and in osmotic stress technique study involved in biological molecules. It can be used as a stabilizing coating to protect metal nanoparticles from oxidation.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Dextran is a glucose polymer biosynthesized by the non-pathogenic Leuconostoc mesenteroides

Application

• Dextran is a complex branched glucan that can be used to enhance electronegativity and reduce erythrocyte aggregation and platelet adhesiveness (anticoagulant activity)
• This compound promotes the activation of plasminogen by inhibiting α-2 antiplasmin
• Dextran can be used to reduce thrombosis in animal models
• It is used in osmotic stress techniques where osmotic pressure is applied to biological molecules
• Dextran can be used as an immobilization agent in biosensors

RUO – Research Use Only

General References:

  1. Zhang, Z.; Amorosa, L. F.; Coyle, S. M.; Macor, M. A.; Lubitz, S. E.; Carson, J. L.; Birnbaum, M. J.; Lee, L. Y.; Haimovich, B. Proteolytic Cleavage of AMPK alpha and Intracellular MMP9 Expression Are Both Required for TLR4-Mediated mTORC1 Activation and HIF-1alpha Expression in Leukocytes. J. Immunol. 2015, 195 (5), 2452-2460.
  2. Kim, N. H.; Pham, N. B.; Quinn, R. J.; Shim, J. S.; Cho, H.; Cho, S. M.; Park, S. W.; Kim, J. H.; Seok, S. H.; Oh, J. W.; Kwon, H. J. The Small Molecule R-(-)-beta-O-Methylsynephrine Binds to Nucleoporin 153 kDa and Inhibits Angiogenesis. Int J Biol Sci. 2015, 11 (9), 1088-1099.