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Isradipine, 98+%, Thermo Scientific Chemicals
L-type calcium channel blocker
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Catalog number J63920.MA
also known as J63920-MA
Price (USD)/ Each
136.00
-
Quantity:
10 mg
Price (USD)/ Each
136.00
Isradipine, 98+%, Thermo Scientific Chemicals
Catalog numberJ63920.MA
Price (USD)/ Each
136.00
-
Chemical Identifiers
CAS75695-93-1
IUPAC Name3-methyl 5-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Molecular FormulaC19H21N3O5
InChI KeyHMJIYCCIJYRONP-UHFFFAOYNA-N
SMILESCOC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC2=NON=C12)C(=O)OC(C)C
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Specifications
Specification Sheet
Specification SheetAssay from Supplier's CofA≥98.0%
FormPowder or crystals or crystalline powder
Proton NMRConforms
Isradipine is a L-type calcium channel blocker, Isradipine has anti-atherosclerotic effects in animals and improves endothelium-mediated nitric oxide (NO)-dependent vasodilation in vitro. Additional studies indicate that Isradipine may provide a neuroprotective effect in a rat model of focal ischemia and that Isradipine produces a dose-dependent sparing of dopamine neuronal fibers and cell bodies.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Isradipine is a L-type calcium channel blocker, Isradipine has anti-atherosclerotic effects in animals and improves endothelium-mediated nitric oxide (NO)-dependent vasodilation in vitro. Additional studies indicate that Isradipine may provide a neuroprotective effect in a rat model of focal ischemia and that Isradipine produces a dose-dependent sparing of dopamine neuronal fibers and cell bodies.
Solubility
Soluble in DMSO
Notes
Protect from heat. Store away from oxidizing agents.
Isradipine is a L-type calcium channel blocker, Isradipine has anti-atherosclerotic effects in animals and improves endothelium-mediated nitric oxide (NO)-dependent vasodilation in vitro. Additional studies indicate that Isradipine may provide a neuroprotective effect in a rat model of focal ischemia and that Isradipine produces a dose-dependent sparing of dopamine neuronal fibers and cell bodies.
Solubility
Soluble in DMSO
Notes
Protect from heat. Store away from oxidizing agents.
RUO – Research Use Only
General References:
- Zuhlke, R.D.; Bouron, A.; Soldatov, N.M.; Reuter, H. Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human α1C subunit gene. FEBS Letters. 1998, 427, (2), 220-224.
- Martine Leroueil-Le Verger.; Laurence Fluckiger.; Young-Il Kim.; Maurice Hoffman.; Philippe Maincent. Preparation and characterization of nanoparticles containing an antihypertensive agent. European Journal of Pharmaceutics and Biopharmaceutics. 1998, 46, (2), 137-143.