Dexamethasone 21-phosphate disodium salt, 98%, Thermo Scientific Chemicals
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Dexamethasone 21-phosphate disodium salt, 98%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Dexamethasone 21-phosphate disodium salt, 98%, Thermo Scientific Chemicals

Dexamethasone 21-phosphate disodium salt, CAS # 2392-39-4, is a synthetic adrenal glucocorticoid with potent anti-inflammatory activity.
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Catalog number J64083.03
also known as J64083-03
Price (USD)/ Each
123.65
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137.00 
Save 13.35 (10%)
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Quantity:
1 g
Request bulk or custom format
Price (USD)/ Each
123.65
Online exclusive
137.00 
Save 13.35 (10%)
Add to cart
Dexamethasone 21-phosphate disodium salt, 98%, Thermo Scientific Chemicals
Catalog numberJ64083.03
Price (USD)/ Each
123.65
Online exclusive
137.00 
Save 13.35 (10%)
-
Add to cart
Chemical Identifiers
CAS2392-39-4
IUPAC Namedisodium (1R,2R,3aS,3bS,9aS,9bR,10S,11aS)-9b-fluoro-1,10-dihydroxy-2,9a,11a-trimethyl-1-[2-(phosphonatooxy)acetyl]-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
Molecular FormulaC22H28FNa2O8P
InChI KeyPLCQGRYPOISRTQ-FCJDYXGNSA-L
SMILES[Na+].[Na+].C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP([O-])([O-])=O
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)White to pale cream
FormCrystals or powder or crystalline powder
Assay from Suppliers CofA≥97.5%
Dexamethasone 21-phosphate disodium salt acts as an inducer of apoptosis and inhibitor of the sodium phosphate symporter. It is used in the treatment of emetic effects of cancer therapy and epicondylitis. Further, it serves as an activator of food, medicine, glucocorticoid and anti inflammatory.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description
Dexamethasone 21-phosphate disodium salt is a sodium phosphate salt form of dexamethasone, considered to be a synthetic adrenal glucocorticoid with anti-inflammatory activity
Application
Dexamethasone 21-phosphate disodium salt binds to specific nuclear steroid receptors, interfering with NF-kB activation and apoptotic pathways
It acts as an inducer of apoptosis and inhibitor of the sodium phosphate symporter
It has been used as a positive control to study its effects on ocular shedding of herpes simplex virus type 1 in the induced reactivation and spontaneous shedding rabbit models
This compound is used to study its protective effects against cisplatin-induced ototoxicity in the inner ear of guinea pigs
RUO – Research Use Only

General References:

  1. Keeler, G.D.; Durdik, J.M.; Stenken, J.A. Localized delivery of dexamethasone-21-phosphate via microdialysis implants in rat induces M(GC) macrophage polarization and alters CCL2 concentrations. Acta Biomater. 2015, 12, 11-20.
  2. Keeler, G. D.; Durdik, J. M.; Stenken, J. A. Effects of delayed delivery of dexamethasone-21-phosphate via subcutaneous microdialysis implants on macrophage activation in rats. Acta Biomater. 2015, 23, 27-37.
  3. Daldal, A., Odabasi, O.; Serbetcioglu, B. The protective effect of intratympanic dexamethasone on cisplatin-induced ototoxicity in guinea pigs. Otolaryngol Head Neck Surg. 2007, 137, (5), 747-52.
  4. Ogawa, N.; Kanki, K.; Honda, K.; Tomooka, Y.; Ryoke, K.; Watanabe, T. Involvement of glucocorticoid in induction of lingual T1R3 in rodents. Eur. J. Pharmacol. 2015, 761, 262-267.