Azadibenzocyclooctyne-NHS ester, with 4 carbon linker is used in various applications like protein-peptide conjugates, antibody-enzyme or antibody-drug conjugates, protein or peptide-oligonucleotide conjugates and surface modification. It is used to introduce cyclooctyne moiety in to biomolecules and amine containing compounds.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Azadibenzocyclooctyne-NHS ester, with 4 carbon linker is used in various applications like protein-peptide conjugates, antibody-enzyme or antibody-drug conjugates, protein or peptide-oligonucleotide conjugates and surface modification. It is used to introduce cyclooctyne moiety in to biomolecules and amine containing compounds.
Solubility
Soluble in dimethyl formamide, terahydrofuran, dimethyl sulfocide and dichloromethane.
Notes
Moisture and heat sensitive. Store in cool place. Incompatible with strong oxidizng agents.
RUO – Research Use Only
Jeon, J.; Kang, J. A.; Shim, H. E.; Nam, Y. R.; Yoon, S.; Kim, H. R.; Lee, D. E.; Park, S. H. Efficient method for iodine radioisotope labeling of cyclooctyne-containing molecules using strain-promoted copper-free click reaction. Bioorg. Med. Chem. 2015, 23 (13), 3303-3308.
Mammen, L.; Bley, K.; Papadopoulos, P.; Schellenberger, F.; Encinas, N.; Butt, H. J.; Weiss, C. K.; Vollmer, D. Functional superhydrophobic surfaces made of Janus micropillars. Soft Matter 2015, 11, 506-515.