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Chloroquine diphosphate salt, 98%, Thermo Scientific Chemicals
Catalog number: J64459.22
100 g, Each
Thermo Scientific Chemicals
Chloroquine diphosphate salt, 98%, Thermo Scientific Chemicals
Catalog number: J64459.22
100 g, Each
Quantity
Catalog number: J64459.22
also known as J64459-22
Price (USD)
272.00
Each
Quantity
-
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Chemical Identifiers
CAS
50-63-5
IUPAC Name
7-chloro-N-[5-(diethylamino)pentan-2-yl]quinolin-4-amine; bis(phosphoric acid)
Molecular Formula
C18H32ClN3O8P2
InChI Key
QKICWELGRMTQCR-UHFFFAOYNA-N
SMILES
OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)NC1=C2C=CC(Cl)=CC2=NC=C1
Specifications
Specification SheetForm
Powder or crystals or crystalline powder
Infrared spectrum
Conforms
Appearance (Color)
White to off-white
Assay (unspecified)
≥97.5%
Loss on Drying
≤2.0%
Description
Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs. It can be used as DNA intercalator & to dissociate antigen antibody complexes without denaturing red blood cell antigens. Chloroquine showed very high antiviral activity against NiV but very little activity against the other viruses at concentrations lower than 20 μM.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Chloroquine diphosphate salt is a DNA intercalator that shows anti-malarial and anti-inflammatory activities.
• It has been described that this compound interferes with the biosynthesis of nucleic acids, suggesting a cellular mechanism of action
Applications
• Chloroquine diphosphate salt is used as a DNA intercalator to dissociate antigen-antibody complexes without denaturing red blood cell antigens
• This compound shows antimalarial activity against Plasmodium falciparum, except against chloroquine-resistant strains. It has been used in in vitro antiplasmodial assays. In parasites, the mechanism of action remains unclear, but this compound can inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemozoin, resulting in the accumulation of toxic heme within the parasite.
• It shows very high anti-viral activity against NiV but lower activity against other viruses at concentrations lower than 20 μM
• Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs
• Chloroquine diphosphate salt has been used in autophagy inhibition studies
RUO – Research Use Only
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