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Cerulenin, 98%, Thermo Scientific Chemicals
Has antibiotic and antifungal properties; inhibits fatty acid and steroid biosynthesis
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Catalog number J64538.LB0
also known as J64538-#0
Price (USD)/ Each
159.00
-
Quantity:
5 mg
Price (USD)/ Each
159.00
Cerulenin, 98%, Thermo Scientific Chemicals
Catalog numberJ64538.LB0
Price (USD)/ Each
159.00
-
Specifications
Chemical Name or MaterialCerulenin
TypeCerulenin
Physical FormPowder
CAS17397-89-6
Health Hazard 1H302
View more
Cerulenin is used as an antifungal antibiotic that inhibits sterol and fatty acids biosynthesis. Cerulenin induces apoptosis in tumor cell lines. It can be a useful biochemical tool with applications for the study of metabolism and function of fatty acids in the bacterial cell membrane and in yeast. An extensive review including the properties, uses, mechanism of action and structure has been reported.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Cerulenin is used as an antifungal antibiotic that inhibits sterol and fatty acids biosynthesis. Cerulenin induces apoptosis in tumor cell lines. It can be a useful biochemical tool with applications for the study of metabolism and function of fatty acids in the bacterial cell membrane and in yeast. An extensive review including the properties, uses, mechanism of action and structure has been reported.
Solubility
Soluble in acetone at 20mg/ml. Also soluble in ethanol, benzene, chloroform, or ethyl acetate.
Notes
Keep container tightly closed. Store in cool, dry conditions in well sealed containers..
Cerulenin is used as an antifungal antibiotic that inhibits sterol and fatty acids biosynthesis. Cerulenin induces apoptosis in tumor cell lines. It can be a useful biochemical tool with applications for the study of metabolism and function of fatty acids in the bacterial cell membrane and in yeast. An extensive review including the properties, uses, mechanism of action and structure has been reported.
Solubility
Soluble in acetone at 20mg/ml. Also soluble in ethanol, benzene, chloroform, or ethyl acetate.
Notes
Keep container tightly closed. Store in cool, dry conditions in well sealed containers..
RUO – Research Use Only
General References:
- Sakari Kauppinen.; Mads Siggaard-Andersen.; Penny von Wettstein-Knowles. β-ketoacyl-ACP synthase I of Escherichia coli: Nucleotide sequence of thefabB gene and identification of the cerulenin binding residue. Carlsberg Research Communications. 1988, 53, (6), 357-370.
- Giuliano D'agnony.; Ira S. Rosenfeld.; Juichi Awaya.; Satoshi Omura.; Roy Vagelos, P. Inhibition of fatty acid synthesis by the antibiotic cerulenin: Specific inactivation of β-ketoacyl-acyl carrier protein synthesize. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1973, 326, (2), 155-166.