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Nisin, 900 I.U./mg, Thermo Scientific Chemicals
Catalog number: J66370.03
1 g, Each
Thermo Scientific Chemicals
Nisin, 900 I.U./mg, Thermo Scientific Chemicals
Catalog number: J66370.03
1 g, Each
Quantity
Catalog number: J66370.03
also known as J66370-03
Price (USD)
55.70
Each
Quantity
-
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Chemical Identifiers
CAS
1414-45-5
IUPAC Name
6-amino-2-{2-[2-(2-{2-[2-({7-[6-amino-2-(2-{2-[(21-{6-amino-2-[(10-{15-[(2Z)-2-(2-amino-3-methylpentanamido)but-2-enamido]-12-(butan-2-yl)-9-methylidene-6-(2-methylpropyl)-5,8,11,14-tetraoxo-1-thia-4,7,10,13-tetraazacyclohexadecane-3-amido}-9-methyl-1,4,11-trioxo-tetradecahydropyrrolo[2,1-i]1-thia-4,7,10-triazacyclotridecan-6-yl)formamido]hexanamido}-15,22-dimethyl-12-(2-methylpropyl)-9-[2-(methylsulfanyl)ethyl]-5,8,11,14,17,20-hexaoxo-1-thia-4,7,10,13,16,19-hexaazacyclodocosan-3-yl)formamido]-3-carbamoylpropanamido}-4-(methylsulfanyl)butanamido)hexanamido]-14-[(1H-imidazol-5-yl)methyl]-4,8,20-trimethyl-3,6,12,15,21-pentaoxo-9,19-dithia-2,5,13,16,22-pentaazabicyclo[9.9.2]docosan-17-yl}formamido)-3-hydroxypropanamido]-3-methylpentanamido}-3-(1H-imidazol-5-yl)propanamido)-3-methylbutanamido]prop-2-enamido}hexanoic acid
Molecular Formula
C143H230N42O37S7
InChI Key
NVNLLIYOARQCIX-GSJOZIGCNA-N
SMILES
CCC(C)C(N)C(=O)NC(=C/C)C(=O)NC1CSCC(NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(NC1=O)C(C)CC)C(=O)NC1C(C)SCC(NC(=O)CNC(=O)C2CCCN2C1=O)C(=O)NC(CCCCN)C(=O)NC1C(C)SCC(NC(=O)CNC(=O)C(CCSC)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC1=O)C(=O)NC(CC(N)=O)C(=O)NC(CCSC)C(=O)NC(CCCCN)C(=O)NC1C(C)SCC2NC(=O)C(NC(=O)C(C)NC1=O)C(C)SCC(NC(=O)C(CC1=CN=CN1)NC2=O)C(=O)NC(CO)C(=O)NC(C(C)CC)C(=O)NC(CC1=CN=CN1)C(=O)NC(C(C)C)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O
Specifications
Specification SheetAppearance (Color)
Pale cream to pale brown
Assay from Suppliers CofA
Sodium Chloride: ≥50.0%
Form
Powder
Assay from Suppliers CofA
Titer: ≥900 IU/mg
Loss on Drying
≤5.0%
Description
Nisin, 900 I.U./mg is commonly used as a food preservative. It is also used as a selective agent in cell culture for the isolation of gram-negative bacteria, yeast, and molds. Nisin has been used in bioassays to study posttranslational modification. It binds and interferes with the permeability of the cytoplasmic membrane.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Nisin is a broad-spectrum polycyclic peptide derived from and produced by Lactococcus lactis that shows antibacterial activity against gram-positive bacteria
Nisin binds lipid II in the cell membrane. After binding it can insert into the membrane, creating a pore
Nisin can efficiently inhibit the growth of gram-positive bacteria, and resistance is rarely observed
Application
• Nisin is commonly used as a selective compound in cell culture to isolate gram-negative bacteria, yeast, and molds (a type of fungus)
• It has been used in bioassays to study posttranslational modification
• This compound has the ability to bind and interfere with the permeability of the cytoplasmic membrane
• It is used to study the assembly and stability of nisin-lipid II pore complexes
• This compound is used in in vitro experiments to form targeted pores in cell membranes that are mediated by lipid II
RUO – Research Use Only
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