Apramycin sulfate, Thermo Scientific Chemicals
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Apramycin sulfate, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Apramycin sulfate, Thermo Scientific Chemicals

Apramycin sulfate, CAS # 65710-07-8, is the salt of apramycin, the bacteriostatic aminoglycoside antibiotic.
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Catalog number J66616.03
also known as J66616-03
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1 g
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Price (USD)/ Each
48.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
56.80 
Save 8.15 (14%)
Add to cart
Apramycin sulfate, Thermo Scientific Chemicals
Catalog numberJ66616.03
Price (USD)/ Each
48.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
56.80 
Save 8.15 (14%)
-
Add to cart
Chemical Identifiers
CAS65710-07-8
IUPAC Name(2R,3R,4S,5S,6S)-2-{[(2R,3S,4R,4aR,6S,7R,8aS)-7-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}-4-hydroxy-3-(methylamino)-octahydropyrano[3,2-b]pyran-2-yl]oxy}-5-amino-6-(hydroxymethyl)oxane-3,4-diol; sulfuric acid
Molecular FormulaC21H43N5O15S
InChI KeyWGLYHYWDYPSNPF-RQFIXDHTSA-N
SMILESOS(O)(=O)=O.CN[C@H]1[C@@H](O)[C@H]2O[C@H](O[C@@H]3[C@@H](N)C[C@@H](N)[C@H](O)[C@H]3O)[C@H](N)C[C@@H]2O[C@@H]1O[C@H]1O[C@H](CO)[C@@H](N)[C@H](O)[C@H]1O
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SpecificationsSpecification SheetSpecification Sheet
Loss on Drying≤ 14%
Appearance (Color)Pale yellow to yellow-brown powder
Potency≥ 550 µg/mg (calculated on dry basis)
FormPowder
Apramycin sulfate binds to the deep groove of RNA and effectively inhibits ribosomal translocation prohibiting protein synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Apramycin is a 2-deoxysteptamine derivative and an aminoglycoside originally isolated from Streptomyces tenebrarius
• Apramycin sulfate is comprised of a bicyclic sugar moiety and a monosubstituted deoxystreptamine attached to a sulfate group

Application

• Apramycin sulfate exhibits antibiotic activity against gram-negative bacteria
• It is suitable for laboratory use against Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa
• It is also used for laboratory study of infectious disease

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
RUO – Research Use Only

General References:

  1. Cracknell VC, Andreotis J, Facibeni G, Owais E, Pradella G. An evaluation of apramycin soluble powder for the treatment of naturally acquired Escherichia coli infections in broilers. J Vet Pharmacol Ther. 1986 Sep;9(3):273-9. doi: 10.1111/j.1365-2885.1986.tb00041.x. PMID: 3531550.
  2. Zhang J, Chen Q. Predicting the long-term toxicity of five-antibiotic mixtures to Vibrio qinghaiensis sp. Q67. Pak J Pharm Sci. 2014 Sep;27(5 Suppl):1605-9. PMID: 25262505.