17-(Allylamino)-17-demethoxygeldanamycin, 99%, Thermo Scientific Chemicals
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17-(Allylamino)-17-demethoxygeldanamycin, 99%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

17-(Allylamino)-17-demethoxygeldanamycin, 99%, Thermo Scientific Chemicals

Possesses anti-tumor activity
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Catalog number J66960.EX3
also known as J66960-!3
Price (USD)/ Each
420.00
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Quantity:
200 mg
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Price (USD)/ Each
420.00
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17-(Allylamino)-17-demethoxygeldanamycin, 99%, Thermo Scientific Chemicals
Catalog numberJ66960.EX3
Price (USD)/ Each
420.00
-
Add to cart
Chemical Identifiers
CAS75747-14-7
IUPAC Name(4Z,6E,8R,9R,10E,12R,13S,14R,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-[(prop-2-en-1-yl)amino]-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
Molecular FormulaC31H43N3O8
InChI KeyAYUNIORJHRXIBJ-CQFHKJEWSA-N
SMILESCO[C@@H]1C[C@H](C)CC2=C(NCC=C)C(=O)C=C(NC(=O)C(C)=C/C=C/[C@@H](OC)[C@H](OC(N)=O)C(C)=C[C@@H](C)[C@@H]1O)C2=O
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)Red to dark red
Assay from Supplier's CofA≥98.5% (HPLC)
FormPowder
17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) inhibits heat shock protein 90 (Hsp90), the expression of heat shock factor-1, and the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. In addition to its anti-tumor effects, 17-AAG also induces apoptosis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in DMSO at 150 mg/mL; soluble in ethanol at 5 mg/mL. Very poorly soluble in water

Notes
Research Use only: Not intended for animal or human diagnostic or therapeutic use.
RUO – Research Use Only

General References:

  1. Theodor W. Schulte.; Leonard M. Neckers. The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin. Cancer Chemotherapy and Pharmacology. 1998, 42, (4), 273-279.
  2. Merrill J. Egorin.; Eleanor G. Zuhowski.; Marc Rosen, D.; Dorothy L. Sentz.; Joseph M. Covey.; Julie L. Eiseman. Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1. Cancer Chemotherapy and Pharmacology. 2001, 47, (4), 291-302.