Novobiocin sodium salt, 20 mg/ml in distilled water, sterile-filtered, Thermo Scientific Chemicals
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Novobiocin sodium salt, 20 mg/ml in distilled water, sterile-filtered, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Novobiocin sodium salt, 20 mg/ml in distilled water, sterile-filtered, Thermo Scientific Chemicals

Novobiocin sodium salt, CAS # 1476-53-5, is a topoisomerase II inhibitor capable of inhibiting DNA synthesis. This compound is produced by Streptomyces nieveus and shows antibiotic activity.
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Catalog number J67381.AE
also known as J67381-AE
Price (USD)/ Each
288.65
Online exclusive
321.00 
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Quantity:
100 mL
Request bulk or custom format
Price (USD)/ Each
288.65
Online exclusive
321.00 
Save 32.35 (10%)
Add to cart
Novobiocin sodium salt, 20 mg/ml in distilled water, sterile-filtered, Thermo Scientific Chemicals
Catalog numberJ67381.AE
Price (USD)/ Each
288.65
Online exclusive
321.00 
Save 32.35 (10%)
-
Add to cart
Specifications
Chemical Name or MaterialNovobiocin sodium salt
TypeNovobiocin Sodium Salt
Name Note20 mg/mL in distilled water, sterile-filtered
Physical FormLiquid
CAS1476-53-5
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This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Novobiocin sodium salt, first isolated from Streptomyces nieveus, is a topoisomerase II inhibitor. It is a coumarin compound showing antibiotic activity
• Novobiocin sodium salt can inhibit DNA synthesis by inhibiting the topoisomerase II enzyme. Its antibacterial activity arises from competitive inhibition of the ATPase reaction catalyzed by the GyrB subunit

Application

• Novobiocin sodium salt is used to inhibit the activity of retroviral RNA-dependent DNA polymerase in laboratory experiments
• It is also used as an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase.
• Novobiocin sodium salt shows anti-staphylococcal activity against methicillin-resistant Staphylococcus aureus, a gram-positive bacterium
• It permits the relaxation of negative DNA supercoils and has been used to generate positively supercoiled DNA
• This compound inhibits the chaperone activity of Hsp90

RUO – Research Use Only

General References:

  1. Lockshon, D., and Morris, D.R. Positively supercoiled plasmid DNA is produced by treatment of Escherichia coli with DNA gyrase inhibitors. Nucleic Acids Res. 1983, 11, (10), 2999-3017.
  2. Allan, R., Mok, D., Ward, B.K., et al. Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: Evidence that coumarin antibiotics disrupt Hsp90 dimerization. J. Biol. Chem. 2006, 281, (11), 7161-7171.
  3. Collin, F., Karkare, S., and Maxwell, A. Exploiting bacterial DNA gyrase as a drug target: Current state and perspectives. Appl. Microbiol. Biotechnol. 2011, 92, (3), 479-497.
  4. Aguirre-Martínez, G. V.; DelValls, A. T.; Martín-Díaz, M. L. Yes, caffeine, ibuprofen, carbamazepine, novobiocin and tamoxifen have an effect on Corbicula fluminea (Müller, 1774). Ecotox. Environ. Safe. 2015, 120, 142-154.
  5. Rymer, J. K.; Hauser, M.; Bourdon, A. K.; Campagna, S. R.; Naider, F.; Becker, J. M. Novobiocin and peptide analogs of alfa-factor are positive allosteric modulators of the yeast G protein-coupled receptor Ste2p. Biochim. Biophys. Acta 2015, 1848 (4), 916-924.