Glutarimide acts as an inhibitor of protein synthesis. Further, it is used as a reactant for thionations and biocatalytic asymmetric synthesis of sitagliptin production. It is also employed in the generation of beta-adrenoceptor ligands, enantioselective synthesis of securinega alkaloids and alfa-fluoro-alfa amino amides. In addition to this, it is used in intramolecular amidocyclopropanation reactions.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Glutarimide acts as an inhibitor of protein synthesis. Further, it is used as a reactant for thionations and biocatalytic asymmetric synthesis of sitagliptin production. It is also employed in the generation of beta-adrenoceptor ligands, enantioselective synthesis of securinega alkaloids and alfa-fluoro-alfa amino amides. In addition to this, it is used in intramolecular amidocyclopropanation reactions.
Solubility
Soluble in water, hot ethanol and boiling benzene. Insoluble in ether.
Notes
Incompatible with strong oxidizing agents.
RUO – Research Use Only
Sundaram, S.; Heine, D.; Hertweck, C. Polyketide synthase chimeras reveal key role of ketosynthase domain in chain branching. Nat. Chem. Biol. 2015, 11, 949-951.
Kortüm, K. M.; Zhu, Y. X.; Shi, C. X.; Jedlowski, P.; Stewart, A. K. Cereblon binding molecules in multiple myeloma. Blood Rev. 2015, 29 (5), 329-334.