N-Methyliminodiacetic acid is used to prepare bis-(1H-benzoimidazol-2-ylmethyl)-methyl-amine by condensation with benzene-1,2-diamine. It is involved in Suzuki cross-coupling with N-methyliminodiacetic acid (MIDA) boronates. It acts as a reagent utilized for protecting boronic acids and as a chelating agent for various metals.
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Applications
N-Methyliminodiacetic acid is used to prepare bis-(1H-benzoimidazol-2-ylmethyl)-methyl-amine by condensation with benzene-1,2-diamine. It is involved in Suzuki cross-coupling with N-methyliminodiacetic acid (MIDA) boronates. It acts as a reagent utilized for protecting boronic acids and as a chelating agent for various metals.
Solubility
Soluble in water. Slightly soluble in dimethyl sulfoxide.
Notes
Incompatible with strong bases.
RUO – Research Use Only
Qi, L.; Zhou, X.; Li, X.; Li, W.; Lv, M.; Guo, M. N-methyliminodiacetic acid as a simple and highly efficient ligand for palladium-catalyzed Suzuki-Miyaura cross-coupling of aryl chlorides. Appl. Organomet. Chem. 2015, 29 (4), 244-246.
Lee, Y. S.; Cheon, C. H. Synthesis of Benzimidazole-Substituted Arylboronic Acids via Aerobic Oxidation of 1, 2-Arylenediamines and Formyl-Substituted Aryl MIDA Boronates using Potassium Iodide as a Catalyst. Adv. Synth. Catal. 2015, 357 (13), 2951-2956.