Abolishes the rapid inactivation of membrane sodium- and potassium-ion channels.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Abolishes the rapid inactivation of membrane sodium- and potassium-ion channels.
Solubility
Soluble in water.
Notes
Store at -20°C. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.
RUO – Research Use Only
D R Matteson; and P Carmeliet. Modification of K channel inactivation by papain and N-bromoacetamide. Biophysical Journal., 1988,53(4), 641-645.
J Tanguy and J Z Yeh. BTX modification of Na channels in squid axons. I. State dependence of BTX action. Journal of General Physiology., 1991,97(3), 499-519.
Source of positive bromine, useful for the conversion of alkenes to bromohydrins under mild conditions: Helv. Chim. Acta, 26, 562, 746, 1799 (1943); Tetrahedron Lett., 765 (1973). It is also a useful reagent for mild oxidation of secondary alcohols to ketones: J. Biol. Chem., 184, 393 (1950); J. Am. Chem. Soc., 76, 3682 (1954); 85, 1409 (1963).
In combination with AgOAc and AcOH, has been used to convert alkenes stereoselectively to cis-1,2-diols: Tetrahedron Lett., 1581 (1976).