Trimethylsilyl isothiocyanate is used as derivatizing reagent during the synthesis of amino acid thiohydantoins. It participates in ring opening reaction of N-substituted aziridines and cyclohexene oxide.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Trimethylsilyl isothiocyanate is used as derivatizing reagent during the synthesis of amino acid thiohydantoins. It participates in ring opening reaction of N-substituted aziridines and cyclohexene oxide.
Solubility
Reacts with water.
Notes
Moisture Sensitive. Incompatible materials are Strong oxidizing agentsAlcohols, Strong bases, Amines, acids.
RUO – Research Use Only
B Mo; J Li; S Liang. A method for preparation of amino acid thiohydantoins from free amino acids activated by acetyl chloride for development of protein C-terminal sequencing.Analytical Biochemistry.1997, 247 (2), 207-211.
Xiaobing Yang; Shaohua Huang; Zhenshan Jia; Zuo Xiao; Zhongping Jiang; Qianyan Zhang, Liangbing Gan; Bo Zhen;, Gu Yuan; Shiwei Zhang. Reactivity of fullerene epoxide: preparation of fullerene-fused thiirane, tetrahydrothiazolidin-2-one, and 1,3-dioxolane.Journal of Organic Chemistry.2008, 73 (7), 2518-2526.
Protected form of “HNCS”.