Iodoacetonitrile is used for alkylation of nucleophiles. It undergoes Reformatsky and Wittig-type reactions with aldehydes.
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Applications
Iodoacetonitrile is used for alkylation of nucleophiles. It undergoes Reformatsky and Wittig-type reactions with aldehydes.
Solubility
Soluble in benzene, alcohol, acetone, ether. Slightly soluble in water. Insoluble in hexane.
Notes
Light Sensitive. Store at 4°C. Incompatible with reducing agents, light and bases. Store away from strong bases.
RUO – Research Use Only
General References:
- Paul G. Wenthold. Determination of the proton affinities of bromo- and iodoacetonitrile using the kinetic method with full entropy analysis.Journal of the American Society for Mass Spectrometry.2000, 11 601-605.
- W. C. Kupferschmidt; R. B. Jordan. Reactions of chromium(II) with chloro- and iodoacetonitrile and their pentaamminecobalt(III) complexes.J. Am. Chem. Soc..1984, 106 (4), 991-995.