2-Naphthoic acid is an unprotected acid undergoes lithiation, e.g. with s-BuLi, by stereospecific 1,4-addition, providing a facile route to 1,2,2-trisubstituted 1,2-dihydronaphthalenes. It is also used as an intermediate in organic synthesis. The fluorescence spectra and electronic absorption of 2-naphthoic acid was studied.
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Applications
2-Naphthoic acid is an unprotected acid undergoes lithiation, e.g. with s-BuLi, by stereospecific 1,4-addition, providing a facile route to 1,2,2-trisubstituted 1,2-dihydronaphthalenes. It is also used as an intermediate in organic synthesis. The fluorescence spectra and electronic absorption of 2-naphthoic acid was studied.
Solubility
Soluble in alcohol, diethyl ether, methanol, and ethyl acetate (20 mg/ml). Insoluble in water.
Notes
Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents.
RUO – Research Use Only
General References:
- Han Yu and Gabriela K Popescu. Inhibition of GluN2A-containing N-methyl-D-aspartate receptors by 2-naphthoic acid. Molecular Pharmacology. 2013, 84,(4), 541-550.
- Carolina Berdugo-Clavijo et. al. Methanogenic biodegradation of two-ringed polycyclic aromatic hydrocarbons. FEMS Microbiology Ecology. 2012, 81,(1), 124-133.
- The unprotected acid undergoes lithiation, e.g. with s-BuLi, by stereospecific 1,4-addition, providing a facile route to 1,2,2-trisubstituted 1,2-dihydronaphthalenes: J. Org. Chem., 61, 5206 (1996).