Acetazolamide acts as a carbonic anhydrase inhibitor which increases cerebral blood flow. It inhibits water permeability of membranes by interacting with aquaporins. It is used for the medical treatment of glaucoma, epileptic seizure, idiopathic intracranial hypertension, altitude sickness, cystinuria.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Solubility
Soluble in NH4OH (50 mg/mL), DMSO, Methanol and slightly soluble in Ethanol.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agents. Incompatible materials are oxidizing agents, bases.
RUO – Research Use Only
General References:
- Junwei Gao; Xiaohua Wang; Yongjie Chang; Jianzhao Zhang; Qianliu Song; Heming Yu; Xuejun Li. Acetazolamide inhibits osmotic water permeability by interaction with aquaporin-1.Analytical Biochemistry.2006, 350 (2), 165-170 .
- S. Nigel Cox, FRCS; Elizabeth Hay, MD; Alan C. Bird, MD. Treatment of Chronic Macular Edema With Acetazolamide.Arch Ophthalmol.1988, 106 (9), 1190-1195.