4-Isopropylcyclohexanone is used to prepare 4-isopropyl-cyclohexanone oxime. It is also used in the synthesis of dihydroindol-2-ones as agonists and antagonist ligands at the nociceptin receptor. Further, it is used in the preparation of beta-alanine derivatives, which acts as orally available glucagon receptor antagonists.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
4-Isopropylcyclohexanone is used to prepare 4-isopropyl-cyclohexanone oxime. It is also used in the synthesis of dihydroindol-2-ones as agonists and antagonist ligands at the nociceptin receptor. Further, it is used in the preparation of beta-alanine derivatives, which acts as orally available glucagon receptor antagonists.
Solubility
Soluble in alcohol. Insoluble in water.
Notes
Incompatible with oxidizing agents. reducing agents and plastics.
RUO – Research Use Only
Chang, S. D.; Mascarella, S. W.; Spangler, S. M.; Gurevich, V. V.; Navarro, H. A.; Carroll, F. I.; Bruchas, M. R. Quantitative Signaling and Structure-Activity Analyses Demonstrate Functional Selectivity at the Nociceptin/Orphanin FQ Opioid Receptor. Mol. Pharmacol. 2015, 88 (3), 502-511.
Zaveri, N. T.; Journigan, V. B.; Polgar, W. E. Discovery of the First Small-Molecule Opioid Pan Antagonist with Nanomolar Affinity at Mu, Delta, Kappa, and Nociceptin Opioid Receptors. ACS Chem. Neurosci. 2015, 6 (4), 646-657.