Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor. It is a potent vasodilator and endogenous histamine receptor agonist.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor. It is a potent vasodilator and endogenous histamine receptor agonist.
Solubility
Very soluble in water and methanol. Soluble in ethanol.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents. Store away from oxidizing agents. Store at 4°C.
RUO – Research Use Only
General References:
- Egla Yareth Bivián-Castro; Mercedes G López; Mario Pedraza-Reyes; Sylvain Bernès; Guillermo Mendoza-Díaz. Synthesis, characterization, and biological activity studies of copper(II) mixed compound with histamine and nalidixic acid.Bioinorganic Chemistry and Applications.2009, 603651.
- Anna Martnera; Fredrik B Thoréna; Johan Aureliusa; Jonas Söderholma; Mats Brunea & Kristoffer Hellstrand. Immunotherapy with histamine dihydrochloride for the prevention of relapse in acute myeloid leukemia.Expert Review of Hematology.2010, 3 381-391.