Applications
Tetra-n-butylammonium fluoride trihydrate is used as a phase transfer catalyst, as a mild base and as a source of fluoride ion in organic solvents. It is also used as a deprotecting agent to remove silyl ether protecting groups. It acts as a reactant for the preparation of deprotecting agents, in preparation of cellulose derivatives, lipophilic peptides for DNA transfections and Dehydrobromination reactions. It plays an important role in the convertion of O-silylated enolates in to carbonyls in the presence of dimethyl sulfoxide.

Solubility
Soluble in water, terahydrofuran, dimethyl sulfoxide and acetonitrile.

Notes
Hygroscopic. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.