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2-Succinimido-1,1,3,3-tetramethyluronium tetrafluoroborate, 98%, Thermo Scientific Chemicals
Catalog number: L13538.14
25 g, Each
Thermo Scientific Chemicals
2-Succinimido-1,1,3,3-tetramethyluronium tetrafluoroborate, 98%, Thermo Scientific Chemicals
Catalog number: L13538.14
25 g, Each
Quantity
Catalog number: L13538.14
also known as L13538-14
Price (USD)
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340.65 360.65 Online priceSave 20.00 (5%)
Ends: 15-Oct-2024
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Chemical Identifiers
CAS
105832-38-0
IUPAC Name
[(dimethylamino)[(2,5-dioxopyrrolidin-1-yl)oxy]methylidene]dimethylazanium; tetrafluoroboranuide
Molecular Formula
C9H16BF4N3O3
InChI Key
YEBLHMRPZHNTEK-UHFFFAOYSA-N
SMILES
F[B-](F)(F)F.CN(C)C(ON1C(=O)CCC1=O)=[N+](C)C
Specifications
Specification SheetForm
Crystalline powder or needles
Assay (HPLC)
≥97.5%
Appearance (Color)
White to pale cream
Melting Point (clear melt)
194-201?C
Description
2-Succinimido-1,1,3,3-tetramethyluronium tetrafluoroborate (TSTU) acts as an efficient coupling agent through rapid activation of carboxylic acids to form N-succinimidyl active esters, which react with primary amines to form carboxamides. It is effective even in the presence of water. TSTU is selective towards amines in the presence of alcoholic group. It is employed as a coupling regent in the synthesis of peptides. With amine-protected alpha-amino acids, it brings about coupling without significant epimerization. It is useful for linking of sensor molecules with amino groups to amino-functionalized AFM (atomic force microscope) tips.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
2-Succinimido-1,1,3,3-tetramethyluronium tetrafluoroborate (TSTU) acts as an efficient coupling agent through rapid activation of carboxylic acids to form N-succinimidyl active esters, which react with primary amines to form carboxamides. It is effective even in the presence of water. TSTU is selective towards amines in the presence of alcoholic group. It is employed as a coupling regent in the synthesis of peptides. With amine-protected alpha-amino acids, it brings about coupling without significant epimerization. It is useful for linking of sensor molecules with amino groups to amino-functionalized AFM (atomic force microscope) tips.
Solubility
Soluble in acetonitrile, DMF, chloroform, dichlorormethane and acetonitrile.
Notes
Moisture sensitive, Incompatible with strong oxidizing agents.
2-Succinimido-1,1,3,3-tetramethyluronium tetrafluoroborate (TSTU) acts as an efficient coupling agent through rapid activation of carboxylic acids to form N-succinimidyl active esters, which react with primary amines to form carboxamides. It is effective even in the presence of water. TSTU is selective towards amines in the presence of alcoholic group. It is employed as a coupling regent in the synthesis of peptides. With amine-protected alpha-amino acids, it brings about coupling without significant epimerization. It is useful for linking of sensor molecules with amino groups to amino-functionalized AFM (atomic force microscope) tips.
Solubility
Soluble in acetonitrile, DMF, chloroform, dichlorormethane and acetonitrile.
Notes
Moisture sensitive, Incompatible with strong oxidizing agents.
RUO – Research Use Only
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