4-(2-Hydroxyethyl)pyridine acts as a reagent for the protection of carboxyl groups as their 2-(4-pyridyl)ethyl esters in organic synthesis. Further, it is used as an active pharmaceutical ingredient intermediate.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
4-(2-Hydroxyethyl)pyridine acts as a reagent for the protection of carboxyl groups as their 2-(4-pyridyl)ethyl esters in organic synthesis. Further, it is used as an active pharmaceutical ingredient intermediate.
Solubility
Miscible with water.
Notes
Hygroscopic. Moisture sensitive. Incompatible with strong oxidizing agents, bases and mineral acids.
RUO – Research Use Only
Reagent for protection of carboxyl groups as their 2-(4-pyridyl)ethyl esters, by reaction with the acid chloride: Tetrahedron Lett., 25, 1223 (1984). See preceding entry under 2-isomer. See also 4-Vinylpyridine, L13316.
Kato, Y.; Kawasaki, M.; Nigo, T.; Nakamura, S.; Fusano, A.; Teranishi, Y.; Ito, M. N.; Sumiyoshi, T. Identification of 2,3-disubstituted pyridines as potent, orally active PDE4 inhibitors. Bioorg. Med. Chem. 2013, 21 (18), 5851-5854.
Aschenbrücker, J.; Steegmüller, U.; Ernsting, N. P.; Buback, M.; Schroeder, J.; Jasny, J. Picosecond UV pump/IR probe spectrometer for the 2-5 mum spectral region. Appl. Phys. B: Lasers Opt. 1997, 65 (4), 441-444.