(S)-(+)-Epichlorohydrin, 98+%, Thermo Scientific Chemicals
(S)-(+)-Epichlorohydrin, 98+%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

(S)-(+)-Epichlorohydrin, 98+%, Thermo Scientific Chemicals

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25 g
Catalog number L14298.03
also known as L14298-03
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(S)-(+)-Epichlorohydrin, 98+%, Thermo Scientific Chemicals
Catalog numberL14298.03
Price (USD)/ Each
60.30
-
Add to cart
Chemical Identifiers
CAS67843-74-7
IUPAC Name(2S)-2-(chloromethyl)oxirane
Molecular FormulaC3H5ClO
InChI KeyBRLQWZUYTZBJKN-GSVOUGTGSA-N
SMILESClC[C@@H]1CO1
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SpecificationsSpecification SheetSpecification Sheet
Assay (GC)≥98.0%
Appearance (Color)Clear colorless
Optical Rotation+35 ? 2? (c=1 in methanol)
Refractive Index1.4355-1.4405 @ 20?C
FormLiquid
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(S)-(+)-Epichlorohydrin is utilized for the synthesis of macquarimicins and hydroxyisoxazolidines and (+)-cis-sylvaticin, which is a potential antitumor agent. It is used to synthesize inhibitors of fatty acid oxidation as potential metabolic modulators. It acts as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels, lacquers and cement for celluloid. It is also used as a stabilizer and also useful as a bifunctional alkylating agent with the potential to form DNA cross-links.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
(S)-(+)-Epichlorohydrin is utilized for the synthesis of macquarimicins and hydroxyisoxazolidines and (+)-cis-sylvaticin, which is a potential antitumor agent. It is used to synthesize inhibitors of fatty acid oxidation as potential metabolic modulators. It acts as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels, lacquers and cement for celluloid. It is also used as a stabilizer and also useful as a bifunctional alkylating agent with the potential to form DNA cross-links.

Solubility
Miscible with chloroform and methanol. Immiscible with water.

Notes
Hygroscopic. Store in a cool place. Incompatible with acids, bases, ammonia, amines, sodium and sodium oxides, zinc, magnesium, aluminum and its alloys and halides.
RUO – Research Use Only

General References:

  1. Xue, F.; Liu, Z. Q.; Wang, Y. J.; Zhu, H. Q.; Wan, N. W.; Zheng, Y. G. Efficient synthesis of (S)-epichlorohydrin in high yield by cascade biocatalysis with halohydrin dehalogenase and epoxide hydrolase mutants. Catal. Commun. 2015, 72, 147-149.
  2. Gajare, V. S.; Khobare, S. R.; Malavika, B.; Rajana, N.; Rao, B. V.; Kumar, U. K. S. A short diastereoselective synthesis of cis-(2S,4S) and cis-(2R,4R)-4-hydroxyprolines. Tetrahedron Lett. 2015, 56 (24), 3743-3746.