Ethyl cyanoformate is used as reagent in the preparation of N-substituted amindinoformic acid and ethyl-4-quinazoline -2-carboxylate.
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Applications
Ethyl cyanoformate is used as reagent in the preparation of N-substituted amindinoformic acid and ethyl-4-quinazoline -2-carboxylate.
Solubility
Miscible with chloroform and methanol.
Notes
Moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong acids, strong bases, strong oxidizing agents and strong reducing agents.
RUO – Research Use Only
Reagent for ethoxycarbonylation of enolate anions: Tetrahedron, 43, 45 (1987). In the presence of ZnCl2, active methylene compounds are converted to ɑ-amino acrylate esters: Tetrahedron. Lett, 2525 (1979).
North, M.; Urwin, S. Kinetics and mechanism of base catalysed ethyl cyanoformate addition to aldehydes. Tetrahedron 2014, 70 (40), 7100-7105.
Ji, N., Yao, L.; He, W.; Li, Y. Bifunctional Schiff base/Ti (IV) catalysts for enantioselective cyanoformylation of aldehydes with ethyl cyanoformate. Appl. Organomet. Chem. 2013, 27 (4), 209-213.