Lithium amide, 95%, Thermo Scientific Chemicals
Lithium amide, 95%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Lithium amide, 95%, Thermo Scientific Chemicals

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Quantity:
500 g
25 g
100 g
Catalog number L16023.36
also known as L16023-36
Price (USD)/ Each
261.00
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Quantity:
500 g
Request bulk or custom format
Price (USD)/ Each
261.00
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Lithium amide, 95%, Thermo Scientific Chemicals
Catalog numberL16023.36
Price (USD)/ Each
261.00
-
Add to cart
Chemical Identifiers
CAS7782-89-0
IUPAC Namelithium(1+) azanide
Molecular FormulaH2LiN
InChI KeyAFRJJFRNGGLMDW-UHFFFAOYSA-N
SMILES[Li+].[NH2-]
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)White to grey
FormPowder (may contain black specks)
Assay (unspecified)≥94.0%
Lithium amide is used in the preparation of active pharmaceutical ingredients and antioxidants. It acts as a catalyst for polymers, as nucleophiles and as strong bases. It serves as a reagent in the synthesis of antiinflamatory and preoresolving protectin D1, chemotype dipeptidyl peptidase IV inhibitors and sterically congested triarylamines. It finds application in dyes displaying large stokes shifts. In addition to this, it is used as a reagent for cross-coupling of aryl chlorides and amine.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Lithium amide is used in the preparation of active pharmaceutical ingredients and antioxidants. It acts as a catalyst for polymers, as nucleophiles and as strong bases. It serves as a reagent in the synthesis of antiinflamatory and preoresolving protectin D1, chemotype dipeptidyl peptidase IV inhibitors and sterically congested triarylamines. It finds application in dyes displaying large stokes shifts. In addition to this, it is used as a reagent for cross-coupling of aryl chlorides and amine.

Solubility
Slightly soluble in ethanol and liquid ammonia. Insoluble in anhydrous ether, benzene and toluene.

Notes
Moisture sensitive. Incompatible with strong oxidizing agents, acids, water and alcohols.
RUO – Research Use Only

General References:

  1. Sasaki, M.; Kondo, Y.; Moto-ishi, T. I.; Kawahata, M.; Yamaguchi, K.; Takeda, K. Enantioselective Synthesis of Allenylenol Silyl Ethers via Chiral Lithium Amide Mediated Reduction of Ynenoyl Silanes and Their Diels-Alder Reactions. Org. Lett. 2015, 17 (5), 1280-1283.
  2. Lesage, D.; Barozzino-Consiglio, G.; Duwald, R.; Fressigné, C.; Harrison-Marchand, A.; Faull, K. F.; Maddaluno, J.; Gimbert, Y. A Lithium Amide Protected Against Protonation in the Gas Phase: Unexpected Effect of LiCl. J. Org. Chem. 2015, 80 (12), 6441-6446.