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1-Chloroisoquinoline, 95%, Thermo Scientific Chemicals
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Catalog number L17831.06
also known as L17831-06
Price (USD)/ Each
127.00
-
Quantity:
5 g
Price (USD)/ Each
127.00
1-Chloroisoquinoline, 95%, Thermo Scientific Chemicals
Catalog numberL17831.06
Price (USD)/ Each
127.00
-
Chemical Identifiers
CAS19493-44-8
IUPAC Name1-chloroisoquinoline
Molecular FormulaC9H6ClN
InChI KeyMSQCQINLJMEVNJ-UHFFFAOYSA-N
SMILESClC1=C2C=CC=CC2=CC=N1
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Specifications
Specification Sheet
Specification SheetMelting Point (clear melt)27.0-39.0?C
FormCrystals or powder or crystalline powder or fused solid
Appearance (Color)Pale yellow to yellow to orange to brown
Assay (GC)≥94.0%
The product has been used in a Mn-catalyzed cross-coupling with aryl- and alkylmagnesium halides. It has also been used in a Pd-catalyzed cross-coupling with heteroaryl boronic acids and esters. Furthermore, it has been used in a homocoupling reaction to yield bis-isoquinoline, each enantiomer of which might be very useful as a chiral ligand for asymmetric synthesis. 1-Chloroisoquinone is used in the preparation of new aminoisoquinolinylurea derivatives which show antiproliferative activity against melanoma cell lines. It can also be applied to the control of storage age and stability of unstable boronic acids.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
The product has been used in a Mn-catalyzed cross-coupling with aryl- and alkylmagnesium halides. It has also been used in a Pd-catalyzed cross-coupling with heteroaryl boronic acids and esters. Furthermore, it has been used in a homocoupling reaction to yield bis-isoquinoline, each enantiomer of which might be very useful as a chiral ligand for asymmetric synthesis. 1-Chloroisoquinone is used in the preparation of new aminoisoquinolinylurea derivatives which show antiproliferative activity against melanoma cell lines. It can also be applied to the control of storage age and stability of unstable boronic acids.
Solubility
Insoluble in water.
Notes
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
The product has been used in a Mn-catalyzed cross-coupling with aryl- and alkylmagnesium halides. It has also been used in a Pd-catalyzed cross-coupling with heteroaryl boronic acids and esters. Furthermore, it has been used in a homocoupling reaction to yield bis-isoquinoline, each enantiomer of which might be very useful as a chiral ligand for asymmetric synthesis. 1-Chloroisoquinone is used in the preparation of new aminoisoquinolinylurea derivatives which show antiproliferative activity against melanoma cell lines. It can also be applied to the control of storage age and stability of unstable boronic acids.
Solubility
Insoluble in water.
Notes
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
RUO – Research Use Only
General References:
- Kelvin Billingsley and Stephen L Buchwald. Highly efficient monophosphine-based catalyst for the palladium-catalyzed suzuki-miyaura reaction of heteroaryl halides and heteroaryl boronic acids and esters.J. Am. Chem. Soc.,2007,129(11), 3358-3366.
- Chang, et al. Homocoupling of aryl iodides and bromides using a palladium/indium bimetallic system.Synth. Commun.,2005,35(13), 1851-1857.