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2,4,5-Trichloropyrimidine, 98%, Thermo Scientific Chemicals
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Catalog number L19506.03
also known as L19506-03
Price (USD)/ Each
44.80
-
Quantity:
1 g
Price (USD)/ Each
44.80
2,4,5-Trichloropyrimidine, 98%, Thermo Scientific Chemicals
Catalog numberL19506.03
Price (USD)/ Each
44.80
-
Chemical Identifiers
CAS5750-76-5
IUPAC Name2,4,5-trichloropyrimidine
Molecular FormulaC4HCl3N2
InChI KeyGIKMWFAAEIACRF-UHFFFAOYSA-N
SMILESClC1=NC=C(Cl)C(Cl)=N1
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Specifications
Specification Sheet
Specification SheetAppearance (Color)Clear colorless to pale yellow
Assay (GC)≥97.5%
Refractive Index1.5715-1.5755 @ 20?C
FormLiquid
2,4,5-Trichloropyrimidine is used in the synthesis of potent and selective anaplastic lymphoma kinase (ALK-5) inhibitors, used as an anti-tumor treatment. It is also used in the synthesis of EGFR inhibitors.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
2,4,5-Trichloropyrimidine is used in the synthesis of potent and selective anaplastic lymphoma kinase (ALK-5) inhibitors, used as an anti-tumor treatment. It is also used in the synthesis of EGFR inhibitors.
Solubility
Not miscible or difficult to mix in water.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with oxidizing agents.
2,4,5-Trichloropyrimidine is used in the synthesis of potent and selective anaplastic lymphoma kinase (ALK-5) inhibitors, used as an anti-tumor treatment. It is also used in the synthesis of EGFR inhibitors.
Solubility
Not miscible or difficult to mix in water.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with oxidizing agents.
RUO – Research Use Only
General References:
- Richard Ducray.; Pascal Boutron.; Myriam Didelot.; Hervé Germain.; Franck Lach.; Maryannick Lamorlette.; Antoine Legriffon.; Mickael Maudet.; Morgan Ménard.; Georges Pasquet.; Fabrice Renaud.; Iain Simpson.; Gail L. Young. A versatile route to 3-(pyrimidin-4-yl)-imidazo[1,2-a]pyridines and 3-(pyrimidin-4-yl)-pyrazolo[1,5-a]pyridines. Tetrahedron Letters. 2010, 51 (36), 4755-4758.
- Eugen F. Mesaros.; Jason P. Burke.; Jonathan D. Parrish.; Benjamin J. Dugan.; Andrew V. Anzalone.; Thelma S. Angeles.; Mark S. Albom.; Lisa D. Aimone.; Matthew R. Quail.; Weihua Wan.; Lihui Lu.; Zeqi Huang.; Mark A. Ator.; Bruce A. Ruggeri.; Mangeng Cheng.; Gregory R. Ott.; Bruce D. Dorsey. Novel 2,3,4,5-tetrahydro-benzo[d]azepine derivatives of 2,4-diaminopyrimidine, selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse models. Bioorganic & Medicinal Chemistry Letters. 2011, 21 (1), 463-466.