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Invitrogen
Serglycin Polyclonal Antibody
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
Product Details
PA5-51452
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Serglycin. Recombinant protein control fragment (Product #RP-93682).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2647139
Product Specific Information
Immunogen sequence: MQKLLKCSRL VLALALILVL ESSVQGYPTR RARYQWVRCN PDSNSANCLE EKGPMFELLP GESNKIPRLR TDLFPKTRIQ DLNRIFPLSE DYSGSGFGSG SGSGSGSGSG FLTEMEQDYQ LVDE
Highest antigen sequence identity to the following orthologs: Mouse - 53%, Rat - 55%.
Target Information
This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hematopoetic proteoglycan core peptide; hematopoetic proteoglycan core protein; Hematopoietic proteoglycan core protein; P.PG; Platelet proteoglycan core protein; proteoglycan 1, secretory granule; proteoglycan protein core for mast cell secretory granule; secretory granule proteoglycan core peptide; Secretory granule proteoglycan core protein; Serglycin; serglycin proteoglycan
Gene Aliases: PPG; PRG; PRG1; SRGN
UniProt ID: (Human) P10124
Entrez Gene ID: (Human) 5552
platelet degranulation
granzyme-mediated apoptotic signaling pathway
protein processing
negative regulation of bone mineralization
biomineral tissue development
mast cell secretory granule organization
protease localization to mast cell secretory granule
T cell secretory granule organization
maintenance of protease location in mast cell secretory granule
maintenance of granzyme B location in T cell secretory granule
negative regulation of cytokine secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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