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Application
FIGURE: 1 / 8
GDAP1 Antibody (PA5-53136) in ICC/IF
Immunofluorecent analysis of GDAP1 in human cell line A549 using GDAP1 Polyclonal Antibody (Product # PA5-53136). Staining shows localization to cytosol and mitochondria.
Product Details
PA5-53136
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GDAP1. Recombinant protein control fragment (Product #RP-90927).
Conjugate
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2641932
Product Specific Information
Immunogen sequence: PLSEHNEPWF MRLNSTGEVP VLIHGENIIC EATQIIDYLE QTFLDERTPR LMPDKESMYY
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 97%.
Target Information
Glutathione S-transferases (GSTs) function to conjugate reduced glutathione to many exogenous and endogenous hydrophobic electrophiles. Although it shares the carboxy and amino-terminal glutathione S-transferase domains, GDAP1 (ganglioside-induced differentiation-associated protein 1) is characterized as a GST-like protein because it contains an extended GST domain II and a predicted transmembrane domain, two characteristics which are unusual for GST family members. GDAP1 may function in a signal transduction pathway that is responsible for ganglioside-induced neurite differentiation and also may play a role in protecting myelin membranes from free-radical damage. Mutations in the gene encoding GDAP1 is the cause of many forms of Charcot-Marie-Tooth disease, a common inherited disorder of the peripheral nervous system that is characterized by reduced nerve conduction velocities, slow progressive distal muscle atrophy and absent deep tendon reflexes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Charcot-Marie-Tooth neuropathy 4A; Ganglioside-induced differentiation-associated protein 1; GDAP1
Gene Aliases: CMT4; CMT4A; CMTRIA; GDAP1
UniProt ID: (Human) Q8TB36
Entrez Gene ID: (Human) 54332
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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