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Product Details
PA5-53293
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PFTK1. Recombinant protein control fragment (Product #RP-91420).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2645427
Product Specific Information
Immunogen sequence: DDTTFDEICV TKMSTRNCQG MDSVIKPLDT IPEDKKVRVQ RTQSTFDPFE KPANQVKRVH SENNACINFK TSSTGKESPK VRRHSSPSSP TSPKFGKADS YEKLEKLGEG SYATVYKGKS KVNG
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 23%.
Target Information
CDK14 (PFTK1)/cyclin Y is a member of the CDC2-related protein kinase family which is expressed primarily in the postnatal and adult nervous system. CDK14 is expressed at high levels in brain, pancreas, kidney, heart, testis, and ovary. CDK14 amino acid residue ser119 is required for its interaction with all four 14-3-3 isoforms, while ser120 may contribute slightly to CDK14 binding. CDK14 acts as a cyclin-dependent kinase that regulates cell cycle progression and cell proliferation. Overexpression of CDK14 predicts resistance to chemotherapy in patients with esophageal squamous cell carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cell division protein kinase 14; Cyclin-dependent kinase 14; hPFTAIRE1; PFTAIRE protein kinase 1; Serine/threonine-protein kinase PFTAIRE-1
Gene Aliases: CDK14; KIAA0834; PFTAIRE1; PFTK1
UniProt ID: (Human) O94921
Entrez Gene ID: (Human) 5218
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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