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Application
FIGURE: 1 / 5
ELAC2 Antibody (PA5-54016) in ICC/IF
Immunofluorecent analysis of ELAC2 in human cell line A-431 using ELAC2 Polyclonal Antibody (Product # PA5-54016). Staining shows localization to nucleoplasm.
Product Details
PA5-54016
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ELAC2. Recombinant protein control fragment (Product #RP-92519).
Conjugate
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2640982
Product Specific Information
Immunogen sequence: WMERFGPDTQ HLVLNENCAS VHNLRSHKIQ TQLNLIHPDI FPLLTSFRCK KEGPTLSVPM VQGECLLKYQ LRPRREWQRD AIITCNPEEF IVEALQLPNF QQSVQEYR
Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 79%.
Target Information
ELAC2 encodes a protein that has a C-terminal domain with tRNA 3 processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: elaC homolog 2; ElaC homolog protein 2; elaC-like protein 2; Heredity prostate cancer protein 2; putative prostate cancer susceptibility protein HPC2/ELAC2; Ribonuclease Z 2; RNase Z 2; tRNA 3 endonuclease 2; tRNase Z (long form); tRNase Z 2; Zinc phosphodiesterase ELAC protein 2
Gene Aliases: COXPD17; ELAC2; ELC2; HPC2
UniProt ID: (Human) Q9BQ52
Entrez Gene ID: (Human) 60528
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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